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- W111014857 abstract "Resistance to chemotherapeutic agents represents a chief cause of mortality in cancer patients with advanced disease. Gene amplification has been shown to be one of the molecular mechanisms for tumors to escape the effect of chemotherapeutic drugs. The amplification and subsequent overexpression of the chemoresistant gene product are likely the results of tumor cell clonal expansion under the selective pressure of chemotherapeutic agents. In the past few decades, researchers have correlated the amplification of several target genes to drug resistance status in in vitro cell culture models. Although it is possible for gene amplification to be a widespread mechanismof chemore-sistance in cancer patients, only a few well-studied examples are presently available. Therefore, the future application of new advances in molecular genetic technology holds promise for the discovery of novel amplified chemoresistant genes, which may significantly affect our understanding of how tumors become chemoresistant as well as provide a molecular platform for customized treatment of cancer patients." @default.
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- W111014857 date "2007-11-08" @default.
- W111014857 modified "2023-09-24" @default.
- W111014857 title "Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance" @default.
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- W111014857 doi "https://doi.org/10.1007/978-1-59745-035-5_28" @default.
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