Matches in SemOpenAlex for { <https://semopenalex.org/work/W111079477> ?p ?o ?g. }
- W111079477 endingPage "56" @default.
- W111079477 startingPage "46" @default.
- W111079477 abstract "Prostate cancer is the second leading cause of cancer-related deaths in men in the U.S. At present, no single or combination therapy has shown efficacy in decreasing disease progression in patients with metastatic disease. A potentially viable approach for treating late-stage prostate cancer is gene therapy. Adenoviruses (Ad) are the most commonly used mode of gene delivery, but progress using this vector has been hampered by concerns over the safety and practicality of viruses including conditionally replicating Ads (CRAds), particularly for intravenous delivery, and the inefficiency of non-viral transfection techniques. Major challenges for effective gene therapy using Ads are the limited infectivity of regular Ad serotype 5 (Ad5) and the inability to specifically deliver the therapeutic directly into diseased tissue without trapping in the liver or elimination by the immune system. The shortcoming in using Ad5 is mostly attributed to a reduction in Coxsackie-adenovirus receptors (CAR) on the surface of cancer cells, which can be mitigated by generating tropism-modified Ads permitting CAR-independent infection of tumor cells. The limitations of systemic gene delivery can now be overcome by using a novel targeted-delivery approach such as ultrasound (US) contrast agents (microbubbles) to deliver effective therapeutic reagents, Ads, or recombinant proteins, combined with ultrasound-targeted microbubble destruction (UTMD), to develop a site-specific therapy in immune competent transgenic mouse models. These unique strategies for enhancing the efficacy of gene therapy provide a direct path to translation from the laboratory into the clinic for developing an effective gene therapy of prostate cancer." @default.
- W111079477 created "2016-06-24" @default.
- W111079477 creator A5015210940 @default.
- W111079477 creator A5022987623 @default.
- W111079477 creator A5031490587 @default.
- W111079477 creator A5033665986 @default.
- W111079477 creator A5036159485 @default.
- W111079477 creator A5057322570 @default.
- W111079477 creator A5058231485 @default.
- W111079477 creator A5061036144 @default.
- W111079477 creator A5069980003 @default.
- W111079477 creator A5073677610 @default.
- W111079477 creator A5076702481 @default.
- W111079477 creator A5082755854 @default.
- W111079477 creator A5090380865 @default.
- W111079477 creator A5091194969 @default.
- W111079477 date "2011-01-01" @default.
- W111079477 modified "2023-10-15" @default.
- W111079477 title "Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic." @default.
- W111079477 cites W1583927081 @default.
- W111079477 cites W1624279568 @default.
- W111079477 cites W1794539469 @default.
- W111079477 cites W1800349098 @default.
- W111079477 cites W1839957286 @default.
- W111079477 cites W1964069216 @default.
- W111079477 cites W1969637872 @default.
- W111079477 cites W1970437076 @default.
- W111079477 cites W1976253176 @default.
- W111079477 cites W1979898371 @default.
- W111079477 cites W1981397338 @default.
- W111079477 cites W1989915580 @default.
- W111079477 cites W1996981135 @default.
- W111079477 cites W2000351472 @default.
- W111079477 cites W2004170517 @default.
- W111079477 cites W2004708951 @default.
- W111079477 cites W2004832301 @default.
- W111079477 cites W2005768073 @default.
- W111079477 cites W2006569353 @default.
- W111079477 cites W2010579356 @default.
- W111079477 cites W2011184161 @default.
- W111079477 cites W2012081777 @default.
- W111079477 cites W2014944687 @default.
- W111079477 cites W2017872266 @default.
- W111079477 cites W2022315435 @default.
- W111079477 cites W2022494582 @default.
- W111079477 cites W2023141450 @default.
- W111079477 cites W2029931954 @default.
- W111079477 cites W2031900842 @default.
- W111079477 cites W2035996374 @default.
- W111079477 cites W2043654385 @default.
- W111079477 cites W2044071797 @default.
- W111079477 cites W2044943819 @default.
- W111079477 cites W2047959564 @default.
- W111079477 cites W2048077855 @default.
- W111079477 cites W2052093717 @default.
- W111079477 cites W2056859858 @default.
- W111079477 cites W2057074963 @default.
- W111079477 cites W2064219151 @default.
- W111079477 cites W2071406873 @default.
- W111079477 cites W2072553587 @default.
- W111079477 cites W2074810910 @default.
- W111079477 cites W2075776905 @default.
- W111079477 cites W2078455874 @default.
- W111079477 cites W2079987784 @default.
- W111079477 cites W2080632821 @default.
- W111079477 cites W2081941885 @default.
- W111079477 cites W2085438294 @default.
- W111079477 cites W2085600315 @default.
- W111079477 cites W2087734193 @default.
- W111079477 cites W2110166030 @default.
- W111079477 cites W2123386912 @default.
- W111079477 cites W2124375652 @default.
- W111079477 cites W2139527351 @default.
- W111079477 cites W2140471620 @default.
- W111079477 cites W2140698516 @default.
- W111079477 cites W2141019354 @default.
- W111079477 cites W2141077451 @default.
- W111079477 cites W2143064142 @default.
- W111079477 cites W2156054486 @default.
- W111079477 cites W2160802204 @default.
- W111079477 cites W2170815810 @default.
- W111079477 cites W2234798757 @default.
- W111079477 cites W2329048545 @default.
- W111079477 cites W2417329899 @default.
- W111079477 cites W2443794740 @default.
- W111079477 cites W4211024301 @default.
- W111079477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4348040" @default.
- W111079477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21276410" @default.
- W111079477 hasPublicationYear "2011" @default.
- W111079477 type Work @default.
- W111079477 sameAs 111079477 @default.
- W111079477 citedByCount "19" @default.
- W111079477 countsByYear W1110794772012 @default.
- W111079477 countsByYear W1110794772013 @default.
- W111079477 countsByYear W1110794772014 @default.
- W111079477 countsByYear W1110794772015 @default.
- W111079477 countsByYear W1110794772018 @default.
- W111079477 countsByYear W1110794772019 @default.