FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1111185855> ?p ?o ?g. }

• W1111185855 endingPage "e0134229" @default.
• W1111185855 startingPage "e0134229" @default.
• W1111185855 abstract "Some Pseudomonas aeruginosa strains including Australian Epidemic Strain-1 (AES-1 or AUS-01) cause persistent chronic infection in cystic fibrosis (CF) patients, with greater morbidity and mortality. Factors conferring persistence are largely unknown. Previously we analysed the transcriptomes of AES-1 grown in Luria broth, nematode growth medium for Caenorhabditis elegans assay (both aerobic) and artificial sputum medium (mainly hypoxic). Transcriptional comparisons included chronic AES-1 strains against PAO1 and acute AES-1 (AES-1R) against its chronic isogen (AES-1M), isolated 10.5 years apart from a CF patient and not eradicated in the meantime. Prominent amongst genes downregulated in AES-1M in all comparisons was homogentisate-1-2-dioxygenase (hmgA); an oxygen-dependent gene known to be mutationally deactivated in many chronic infection strains of P. aeruginosa. To investigate if hmgA downregulation and deactivation gave similar virulence persistence profiles, a hmgA mutant made in UCBPP-PA14 utilising RedS-recombinase and AES-1M were assessed in the C. elegans virulence assay, and the C57BL/6 mouse for pulmonary colonisation and TNF-α response. In C. elegans, hmgA deactivation resulted in significantly increased PA14 virulence while hmgA downregulation reduced AES-1M virulence. AES-1M was significantly more persistent in mouse lung and showed a significant increase in TNF-α (p<0.0001), sustained even with no detectable bacteria. PA14ΔhmgA did not show increased TNF-α. This study suggests that hmgA may have a role in P. aeruginosa persistence in chronic infection and the results provide a starting point for clarifying the role of hmgA in chronic AES-1." @default.
• W1111185855 created "2016-06-24" @default.
• W1111185855 creator A5002505150 @default.
• W1111185855 creator A5005859384 @default.
• W1111185855 creator A5013642588 @default.
• W1111185855 creator A5037395365 @default.
• W1111185855 creator A5040482619 @default.
• W1111185855 creator A5083064985 @default.
• W1111185855 creator A5083117967 @default.
• W1111185855 creator A5085232583 @default.
• W1111185855 date "2015-08-07" @default.
• W1111185855 modified "2023-10-14" @default.
• W1111185855 title "Homogentisate 1-2-Dioxygenase Downregulation in the Chronic Persistence of Pseudomonas aeruginosa Australian Epidemic Strain-1 in the CF Lung" @default.
• W1111185855 cites W1600560134 @default.
• W1111185855 cites W1969295342 @default.
• W1111185855 cites W1978046264 @default.
• W1111185855 cites W1991922140 @default.
• W1111185855 cites W1993609915 @default.
• W1111185855 cites W2005561077 @default.
• W1111185855 cites W2031043669 @default.
• W1111185855 cites W2039869367 @default.
• W1111185855 cites W2071096810 @default.
• W1111185855 cites W2078891365 @default.
• W1111185855 cites W2083320072 @default.
• W1111185855 cites W2091990251 @default.
• W1111185855 cites W2097944090 @default.
• W1111185855 cites W2101212733 @default.
• W1111185855 cites W2109013949 @default.
• W1111185855 cites W2109383062 @default.
• W1111185855 cites W2116013910 @default.
• W1111185855 cites W2122992192 @default.
• W1111185855 cites W2136570717 @default.
• W1111185855 cites W2139426378 @default.
• W1111185855 cites W2144692447 @default.
• W1111185855 cites W2148998200 @default.
• W1111185855 cites W2151652670 @default.
• W1111185855 cites W2154492506 @default.
• W1111185855 cites W2155824174 @default.
• W1111185855 cites W2163458252 @default.
• W1111185855 cites W2164057520 @default.
• W1111185855 cites W2165029829 @default.
• W1111185855 cites W2182355171 @default.
• W1111185855 cites W2620241325 @default.
• W1111185855 doi "https://doi.org/10.1371/journal.pone.0134229" @default.
• W1111185855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4529145" @default.
• W1111185855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26252386" @default.
• W1111185855 hasPublicationYear "2015" @default.
• W1111185855 type Work @default.
• W1111185855 sameAs 1111185855 @default.
• W1111185855 citedByCount "7" @default.
• W1111185855 countsByYear W11111858552015 @default.
• W1111185855 countsByYear W11111858552016 @default.
• W1111185855 countsByYear W11111858552017 @default.
• W1111185855 countsByYear W11111858552018 @default.
• W1111185855 countsByYear W11111858552021 @default.
• W1111185855 crossrefType "journal-article" @default.
• W1111185855 hasAuthorship W1111185855A5002505150 @default.
• W1111185855 hasAuthorship W1111185855A5005859384 @default.
• W1111185855 hasAuthorship W1111185855A5013642588 @default.
• W1111185855 hasAuthorship W1111185855A5037395365 @default.
• W1111185855 hasAuthorship W1111185855A5040482619 @default.
• W1111185855 hasAuthorship W1111185855A5083064985 @default.
• W1111185855 hasAuthorship W1111185855A5083117967 @default.
• W1111185855 hasAuthorship W1111185855A5085232583 @default.
• W1111185855 hasBestOaLocation W11111858551 @default.
• W1111185855 hasConcept C104317684 @default.
• W1111185855 hasConcept C127561419 @default.
• W1111185855 hasConcept C2777637488 @default.
• W1111185855 hasConcept C523546767 @default.
• W1111185855 hasConcept C54355233 @default.
• W1111185855 hasConcept C60987743 @default.
• W1111185855 hasConcept C86803240 @default.
• W1111185855 hasConcept C89423630 @default.
• W1111185855 hasConceptScore W1111185855C104317684 @default.
• W1111185855 hasConceptScore W1111185855C127561419 @default.
• W1111185855 hasConceptScore W1111185855C2777637488 @default.
• W1111185855 hasConceptScore W1111185855C523546767 @default.
• W1111185855 hasConceptScore W1111185855C54355233 @default.
• W1111185855 hasConceptScore W1111185855C60987743 @default.
• W1111185855 hasConceptScore W1111185855C86803240 @default.
• W1111185855 hasConceptScore W1111185855C89423630 @default.
• W1111185855 hasIssue "8" @default.
• W1111185855 hasLocation W11111858551 @default.
• W1111185855 hasLocation W11111858552 @default.
• W1111185855 hasLocation W11111858553 @default.
• W1111185855 hasLocation W11111858554 @default.
• W1111185855 hasLocation W11111858555 @default.
• W1111185855 hasLocation W11111858556 @default.
• W1111185855 hasOpenAccess W1111185855 @default.
• W1111185855 hasPrimaryLocation W11111858551 @default.
• W1111185855 hasRelatedWork W1896797043 @default.
• W1111185855 hasRelatedWork W1941223470 @default.
• W1111185855 hasRelatedWork W1974885234 @default.
• W1111185855 hasRelatedWork W2025113150 @default.
• W1111185855 hasRelatedWork W2163902276 @default.
• W1111185855 hasRelatedWork W2624354487 @default.
• W1111185855 hasRelatedWork W2941647610 @default.
• W1111185855 hasRelatedWork W3141517888 @default.

• next