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- W111138145 abstract "Publisher Summary Protein phosphorylation (PTP) on tyrosine residues is essential for normal cell signaling, and has a pivotal role in all aspects of cell biology. PTP knockout models in the mouse have led to important breakthroughs in our understanding of the role of PTPs in vivo. However, often redundancy among PTPs obscures elucidation of PTP function. Many PTPs are involved in cell adhesion, which may be reflected by defects in cell migration. This chapter concerns the zebrafish model and investigates the function of PTPs in vertebrates in vivo. It reviews the advantages of the zebrafish as a model system, the conservation of the PTP family in zebrafish, and the initial work that is done to assess the function of PTPs in zebrafish. The study indicates the new directions of PTP research in zebrafish and shows how this will affect analysis of PTP function in higher vertebrates. The zebrafish is being developed as a model system for intravital imaging because of its unique properties, including rapid development and transparency of the embryos." @default.
- W111138145 created "2016-06-24" @default.
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- W111138145 date "2010-01-01" @default.
- W111138145 modified "2023-09-24" @default.
- W111138145 title "Zebrafish and Phosphatase Function" @default.
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- W111138145 doi "https://doi.org/10.1016/b978-0-12-374145-5.00101-7" @default.
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