Matches in SemOpenAlex for { <https://semopenalex.org/work/W111195044> ?p ?o ?g. }
- W111195044 abstract "Common cancers, including breast, lung, and prostate cancers, frequently metastasize to multiple bones where they can cause significant and life-altering pain. Similar to cancer, the factors that drive bone cancer pain evolve and change with disease progression. Once cancer cells have metastasized to bone, both the cancer cells and their associated stromal cells can generate pain by releasing algogenic substances including protons, bradykinin, endothelins, prostaglandins, proteases, and tyrosine kinase activators. The release of these factors by cancer cells and their associated stromal cells can induce sensitization and activation of nerve fibers that innervate the bone. Additionally, these factors can promote a remarkable increase in the number, size, and activity of bone-destroying osteoclasts, which can ultimately result in fracture of the tumor-bearing bone. Tumor growth in bone can also generate a neuropathic pain by directly injuring nerve fibers and inducing a highly pathological sprouting of both sensory and sympathetic nerve fibers that typically innervate the bone. This structural reorganization of sensory and sympathetic nerve fibers in the bone, in conjunction with the cellular and neurochemical reorganization that occurs in the spinal cord and brain, appears to contribute to the peripheral and central sensitization that is common in advanced bone cancer pain. These mechanistic insights have begun to lead to advances in how we understand and treat bone cancer pain." @default.
- W111195044 created "2016-06-24" @default.
- W111195044 creator A5001419149 @default.
- W111195044 creator A5080551226 @default.
- W111195044 creator A5084543586 @default.
- W111195044 creator A5085482533 @default.
- W111195044 date "2015-01-01" @default.
- W111195044 modified "2023-09-24" @default.
- W111195044 title "Bone cancer: current opinion in palliative care" @default.
- W111195044 cites W1577265851 @default.
- W111195044 cites W159669037 @default.
- W111195044 cites W1606824060 @default.
- W111195044 cites W1883044208 @default.
- W111195044 cites W1885155229 @default.
- W111195044 cites W1896223819 @default.
- W111195044 cites W1963857381 @default.
- W111195044 cites W1964443156 @default.
- W111195044 cites W1964947424 @default.
- W111195044 cites W1965352187 @default.
- W111195044 cites W1970360986 @default.
- W111195044 cites W1972533518 @default.
- W111195044 cites W1977202592 @default.
- W111195044 cites W1977621996 @default.
- W111195044 cites W1980584604 @default.
- W111195044 cites W1982915376 @default.
- W111195044 cites W1989013208 @default.
- W111195044 cites W1990177635 @default.
- W111195044 cites W1991925106 @default.
- W111195044 cites W1994993130 @default.
- W111195044 cites W1998703243 @default.
- W111195044 cites W2000144084 @default.
- W111195044 cites W2004015317 @default.
- W111195044 cites W20048007 @default.
- W111195044 cites W2005524625 @default.
- W111195044 cites W2006825597 @default.
- W111195044 cites W2008570007 @default.
- W111195044 cites W2008886334 @default.
- W111195044 cites W2008955660 @default.
- W111195044 cites W2009377647 @default.
- W111195044 cites W2013411637 @default.
- W111195044 cites W2020030503 @default.
- W111195044 cites W2023338676 @default.
- W111195044 cites W2023966862 @default.
- W111195044 cites W2025375792 @default.
- W111195044 cites W2025768466 @default.
- W111195044 cites W2026009169 @default.
- W111195044 cites W2030565784 @default.
- W111195044 cites W2033573454 @default.
- W111195044 cites W2033727415 @default.
- W111195044 cites W2035131069 @default.
- W111195044 cites W2035210392 @default.
- W111195044 cites W2037006205 @default.
- W111195044 cites W2038948426 @default.
- W111195044 cites W2042681077 @default.
- W111195044 cites W2050303640 @default.
- W111195044 cites W2050725524 @default.
- W111195044 cites W2051581510 @default.
- W111195044 cites W2053916112 @default.
- W111195044 cites W2055048745 @default.
- W111195044 cites W2058470031 @default.
- W111195044 cites W2062265555 @default.
- W111195044 cites W2068522538 @default.
- W111195044 cites W2070506825 @default.
- W111195044 cites W2074027763 @default.
- W111195044 cites W2083499857 @default.
- W111195044 cites W2085393173 @default.
- W111195044 cites W2087455247 @default.
- W111195044 cites W2090291376 @default.
- W111195044 cites W2092686636 @default.
- W111195044 cites W2093877466 @default.
- W111195044 cites W2096932694 @default.
- W111195044 cites W2103998574 @default.
- W111195044 cites W2104457567 @default.
- W111195044 cites W2104691397 @default.
- W111195044 cites W2106478572 @default.
- W111195044 cites W2106787323 @default.
- W111195044 cites W2113701976 @default.
- W111195044 cites W2113723285 @default.
- W111195044 cites W2116833068 @default.
- W111195044 cites W2119717385 @default.
- W111195044 cites W2124310658 @default.
- W111195044 cites W2125182431 @default.
- W111195044 cites W2125242933 @default.
- W111195044 cites W2130687125 @default.
- W111195044 cites W2132589643 @default.
- W111195044 cites W2137979524 @default.
- W111195044 cites W2141300182 @default.
- W111195044 cites W2143841439 @default.
- W111195044 cites W2147599802 @default.
- W111195044 cites W2149775776 @default.
- W111195044 cites W2150271931 @default.
- W111195044 cites W2152632692 @default.
- W111195044 cites W2154407477 @default.
- W111195044 cites W2155992320 @default.
- W111195044 cites W2156965630 @default.
- W111195044 cites W2158734599 @default.
- W111195044 cites W2165011173 @default.
- W111195044 cites W2165471060 @default.
- W111195044 cites W2169491449 @default.
- W111195044 cites W2170147411 @default.