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- W111228305 abstract "Arterial calcification is the result of the same highly organized processes as seen in bone, which rely on a delicate balance between osteoblasts and osteoclasts. Although previously understood as passive precipitation, evidence has accumulated to suggest that arterial calcification is the result of organized, regulated processes bearing many similarities to osteogenesis in bone, including the presence of subpopulations of arterial wall cells that retain osteoblastic lineage potential. These cells have the potential to form mineralized nodules and express osteoblast markers, including bone morphogenetic protein-2, osteocalcin, osteopontin, and alkaline phosphatase. By contrast, osteoclast-like cells mediate the catabolic process of mineral resorption. Recent data shows that cells positive for tartrate-resistant acid phosphatase, a major marker for osteoclasts, have been histologically identified in atherosclerotic lesions and are referred to as osteoclast-like cells. Evidence has accumulated to suggest that initial arterial calcification through passive precipitation of calcium phosphate initiates balanced mineralization regulated by osteoclast-like and osteoblast-like cells. Subsequently, various pathogenic conditions may trigger an imbalance between osteoblastogenesis and osteoclastogenesis, leading to either calcification in stenotic/occlusive disease or destruction of the extracellular matrix in aneurysmal disease. Further elucidation of these newly emerging concepts could lead to a novel therapeutic approach to arterial stenotic/occlusive disease and/or abdominal aortic aneurysm. (Circ J 2012; 76: 2732–2737)" @default.
- W111228305 created "2016-06-24" @default.
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- W111228305 creator A5042205831 @default.
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- W111228305 date "2012-01-01" @default.
- W111228305 modified "2023-09-27" @default.
- W111228305 title "Balanced Mineralization in the Arterial System" @default.
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- W111228305 doi "https://doi.org/10.1253/circj.cj-12-1240" @default.
- W111228305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23117745" @default.
- W111228305 hasPublicationYear "2012" @default.
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