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- W111542568 abstract "Acetyl salicylic acid (ASA) was encapsulated with cellulose acetate phthalate (CAP), ethylcellulose (EC) or their mixtures by an emulsion non-solvent addition method. The release profiles of ASA from prepared microcapsules with different ratios of drug to polymer (10:1 and 4:1) and tableted microcapsules were evaluated at pH 1.2 or 6. The results showed that a reduction in the ratio of drug to polymer resulted in a reduction in release rate. The microcapsules prepared with EC showed the lowest release rate. The in vitro release studies showed that the drug release rate decreased after tableting, because of the formation of a non-disintegrating matrix. Release of ASA at pH 6 is significantly higher in all microcapsules, even when using EC which is not water soluble. This is probably due to higher solubility of ASA at pH 6 indicating incomplete film formation around the ASA particles. Release data were examined kinetically and the ideal" @default.
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- W111542568 date "2002-06-20" @default.
- W111542568 modified "2023-10-18" @default.
- W111542568 title "Evaluación de microcápsulas de ácido acetilsalicílico preparadas con eftalato de acetilcelulosa, etilcelulosa o sus mezclas, mediante una técnica de adición de emulsión no disolvente" @default.
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