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- W111643425 abstract "The purpose of this project was to investigate the role of the Checkpoint Suppressor 1 (Ches1) gene in mammalian development. The Ches1 gene belongs to the fork head transcription factor family and has been implicated in controlling the G2-M phase of the cell cycle in lower eukaryotes. Furthermore, Ches1 has been shown to bind the Sin3/Rpd3 HDAC complex in an inhibitory manner in yeast. I n human tumor cell lines, Ches 1 appears to negatively regulate gene expression through the recruitment of SKIP. While the functional role of Ches1 (Foxn3) in higher mammalian models is not well understood, it is under-expressed in both renal cell and oral squamous cell carcinomas. Our initial analysis indicates that we have generated Ches 1 mutant mice, and we plan to characterize the mutant mice for phenotypes that relate to developmental disorders as well as cancer formation. Our preliminary data suggests that loss of Ches1 results in embryonic lethality in mice. Our studies on the expression pattern of Ches1 in 11.5 days post coitum embryos show marked expression of Ches1 throughout the spinal cord. Observations of our Ches1 mutant colony have resulted in the phenotypic characterization of distinct skeletal abnormalities in Ches1 heterozygotes. Future experiments will test our deduction of embryonic lethality, will further characterize Ches1 expression in embryonic development, and will address cancer susceptibility." @default.
- W111643425 created "2016-06-24" @default.
- W111643425 creator A5005662185 @default.
- W111643425 date "2006-01-01" @default.
- W111643425 modified "2023-09-25" @default.
- W111643425 title "Functional Analysis of CHES1 During Mouse Development" @default.
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- W111643425 hasPublicationYear "2006" @default.
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