Matches in SemOpenAlex for { <https://semopenalex.org/work/W111766421> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W111766421 abstract "Abstract : This proposal dealt with the testing of selected chemicals for their possible toxic effects on humans through the use of established mouse (HEPA-2) and human (HEP-G2) liver cell lines. The objective of the work was to eliminate the use of long-term more costly animal models to assess chemical toxicity. These established liver cell lines were chosen or use in this project because they are well characterized biochemically, and continue to express many of the normal functions carried out by the liver. The human HEP-G2 cells are known to secrete 17 different major plasma proteins into the culture medium. The HEPA-2 mouse cells are known to synthesize and to secrete albumin, alpha-fetoprotein, transferrin, ceruloplasmin and haptoglobin while being cultured. Most of the proposed work dealt with the activation of specific detoxifying enzymes of the liver that are involved in the metabolism of xenobiotics. On the other hand, not all hepatotoxins induce these enzyme systems while causing various forms of alteration in the hepatocytes. Therefore, alterations in the expression of the liver-specific functions listed above. Biochemical testing; Toxic chemicals; Mammalian liver cells; Tissue-specific functions; HepatotoxicitY; RA 3 Cytotoxicity; Mouse cell line HEPA-2; Human celline HEP-G2." @default.
- W111766421 created "2016-06-24" @default.
- W111766421 creator A5048446826 @default.
- W111766421 date "1992-04-09" @default.
- W111766421 modified "2023-09-27" @default.
- W111766421 title "Biochemical Testing of Potentially Hazardous Chemicals for Toxicity Using Mammalian Liver Cell Cultures." @default.
- W111766421 hasPublicationYear "1992" @default.
- W111766421 type Work @default.
- W111766421 sameAs 111766421 @default.
- W111766421 citedByCount "0" @default.
- W111766421 crossrefType "journal-article" @default.
- W111766421 hasAuthorship W111766421A5048446826 @default.
- W111766421 hasConcept C109316439 @default.
- W111766421 hasConcept C126322002 @default.
- W111766421 hasConcept C149971331 @default.
- W111766421 hasConcept C178790620 @default.
- W111766421 hasConcept C181674461 @default.
- W111766421 hasConcept C185592680 @default.
- W111766421 hasConcept C202751555 @default.
- W111766421 hasConcept C203014093 @default.
- W111766421 hasConcept C22814914 @default.
- W111766421 hasConcept C2776029263 @default.
- W111766421 hasConcept C2776200302 @default.
- W111766421 hasConcept C2778351090 @default.
- W111766421 hasConcept C29730261 @default.
- W111766421 hasConcept C2992672570 @default.
- W111766421 hasConcept C49039625 @default.
- W111766421 hasConcept C54355233 @default.
- W111766421 hasConcept C55493867 @default.
- W111766421 hasConcept C71924100 @default.
- W111766421 hasConcept C81885089 @default.
- W111766421 hasConcept C86803240 @default.
- W111766421 hasConceptScore W111766421C109316439 @default.
- W111766421 hasConceptScore W111766421C126322002 @default.
- W111766421 hasConceptScore W111766421C149971331 @default.
- W111766421 hasConceptScore W111766421C178790620 @default.
- W111766421 hasConceptScore W111766421C181674461 @default.
- W111766421 hasConceptScore W111766421C185592680 @default.
- W111766421 hasConceptScore W111766421C202751555 @default.
- W111766421 hasConceptScore W111766421C203014093 @default.
- W111766421 hasConceptScore W111766421C22814914 @default.
- W111766421 hasConceptScore W111766421C2776029263 @default.
- W111766421 hasConceptScore W111766421C2776200302 @default.
- W111766421 hasConceptScore W111766421C2778351090 @default.
- W111766421 hasConceptScore W111766421C29730261 @default.
- W111766421 hasConceptScore W111766421C2992672570 @default.
- W111766421 hasConceptScore W111766421C49039625 @default.
- W111766421 hasConceptScore W111766421C54355233 @default.
- W111766421 hasConceptScore W111766421C55493867 @default.
- W111766421 hasConceptScore W111766421C71924100 @default.
- W111766421 hasConceptScore W111766421C81885089 @default.
- W111766421 hasConceptScore W111766421C86803240 @default.
- W111766421 hasLocation W1117664211 @default.
- W111766421 hasOpenAccess W111766421 @default.
- W111766421 hasPrimaryLocation W1117664211 @default.
- W111766421 hasRelatedWork W1709826861 @default.
- W111766421 hasRelatedWork W1971918818 @default.
- W111766421 hasRelatedWork W1977674251 @default.
- W111766421 hasRelatedWork W1989238416 @default.
- W111766421 hasRelatedWork W2027254129 @default.
- W111766421 hasRelatedWork W2045055151 @default.
- W111766421 hasRelatedWork W2076013350 @default.
- W111766421 hasRelatedWork W2079139840 @default.
- W111766421 hasRelatedWork W2103895990 @default.
- W111766421 hasRelatedWork W2146935325 @default.
- W111766421 hasRelatedWork W2167169732 @default.
- W111766421 hasRelatedWork W2274894496 @default.
- W111766421 hasRelatedWork W2411492044 @default.
- W111766421 hasRelatedWork W2414062683 @default.
- W111766421 hasRelatedWork W2436094494 @default.
- W111766421 hasRelatedWork W2564309630 @default.
- W111766421 hasRelatedWork W287688627 @default.
- W111766421 hasRelatedWork W2918274969 @default.
- W111766421 hasRelatedWork W2930045101 @default.
- W111766421 hasRelatedWork W335354903 @default.
- W111766421 isParatext "false" @default.
- W111766421 isRetracted "false" @default.
- W111766421 magId "111766421" @default.
- W111766421 workType "article" @default.