Matches in SemOpenAlex for { <https://semopenalex.org/work/W111826862> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W111826862 abstract "Purpose: To characterize the rate of scotopic sensitivity decline with age using cathode-ray-tube (CRT)-based dark adaptometry and compare the results with the macular pigment optical density (MPOD). Methods: Thresholds were measured following a minimum of 30% bleach, using a white 1� stimulus (flickering at 1 Hz), presented 11� below fixation on a CRT monitor. MPOD was measured using MPS 9000 based on heterochromatic flicker photometry. 33 subjects were divided into two groups: older (?45, n = 16) and younger (<45, n = 17).Results: Rod recovery (slope of S2) was 0.04 log10 units min-1 (p < 0.001) slower in the older (0.19 �0.03 log10 units min-1) compared with the younger group (0.23 �0.03 log10 units min-1). Faster rates of S2 were correlated with lower thresholds (r = 0.49, p < 0.005). The average MPOD for the whole group was 0.37 �0.21. Subjects with lighter irides had on average 40% lower MPOD compared with darker irides. There was a weak relationship between MPOD and final threshold and MPOD and rate of S2. The rate of S2 recovery for the lower 10th percentile of MPOD was significantly slower compared with the upper 10th percentile (p = 0.037). Conclusion: Dark adaptation abnormalities in normal ageing may be related to structural changes in the Bruch?s membrane/Retinal Pigment Epithelium complex subsequent to oxidative stress. Macular pigment is a powerful antioxidant therefore augmentation of MPOD could have beneficial effects on scotopic vision in the elderly. Longitudinal, placebo-controlled intervention studies are needed to explore this possibility." @default.
- W111826862 created "2016-06-24" @default.
- W111826862 creator A5059471997 @default.
- W111826862 date "2011-09-16" @default.
- W111826862 modified "2023-09-26" @default.
- W111826862 title "Potential role of macular pigment in preserving rod-dominated dark adaptation in the older eye" @default.
- W111826862 hasPublicationYear "2011" @default.
- W111826862 type Work @default.
- W111826862 sameAs 111826862 @default.
- W111826862 citedByCount "0" @default.
- W111826862 crossrefType "journal-article" @default.
- W111826862 hasAuthorship W111826862A5059471997 @default.
- W111826862 hasConcept C118487528 @default.
- W111826862 hasConcept C126322002 @default.
- W111826862 hasConcept C2776403814 @default.
- W111826862 hasConcept C2780827179 @default.
- W111826862 hasConcept C500499127 @default.
- W111826862 hasConcept C71924100 @default.
- W111826862 hasConcept C7243750 @default.
- W111826862 hasConcept C86803240 @default.
- W111826862 hasConceptScore W111826862C118487528 @default.
- W111826862 hasConceptScore W111826862C126322002 @default.
- W111826862 hasConceptScore W111826862C2776403814 @default.
- W111826862 hasConceptScore W111826862C2780827179 @default.
- W111826862 hasConceptScore W111826862C500499127 @default.
- W111826862 hasConceptScore W111826862C71924100 @default.
- W111826862 hasConceptScore W111826862C7243750 @default.
- W111826862 hasConceptScore W111826862C86803240 @default.
- W111826862 hasLocation W1118268621 @default.
- W111826862 hasOpenAccess W111826862 @default.
- W111826862 hasPrimaryLocation W1118268621 @default.
- W111826862 hasRelatedWork W1140835634 @default.
- W111826862 hasRelatedWork W125060395 @default.
- W111826862 hasRelatedWork W1563147349 @default.
- W111826862 hasRelatedWork W1970330303 @default.
- W111826862 hasRelatedWork W1977543505 @default.
- W111826862 hasRelatedWork W2002848418 @default.
- W111826862 hasRelatedWork W2008088358 @default.
- W111826862 hasRelatedWork W2012778659 @default.
- W111826862 hasRelatedWork W2013186982 @default.
- W111826862 hasRelatedWork W2017588977 @default.
- W111826862 hasRelatedWork W2019533094 @default.
- W111826862 hasRelatedWork W2044725181 @default.
- W111826862 hasRelatedWork W2060427818 @default.
- W111826862 hasRelatedWork W2152574997 @default.
- W111826862 hasRelatedWork W2156586809 @default.
- W111826862 hasRelatedWork W2246166114 @default.
- W111826862 hasRelatedWork W2350972080 @default.
- W111826862 hasRelatedWork W2761310515 @default.
- W111826862 hasRelatedWork W3876020 @default.
- W111826862 hasRelatedWork W98597528 @default.
- W111826862 isParatext "false" @default.
- W111826862 isRetracted "false" @default.
- W111826862 magId "111826862" @default.
- W111826862 workType "article" @default.