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- W11191547 abstract "Suggestions that diabetes of younger- and older-onset are inherited differently have been examined in a family study which compares the first-degree relatives of 735 diabetic patients with those of 514 ‘control’ patients. Verbally reported histories from the propositi indicated an excess prevalence of known diabetes among the siblings of younger-onset diabetics; however, when the ostensibly normal, first-degree relatives were examined a high frequency of unsuspected glucose tolerance test abnormality was found. When the diabetes prevalence in relatives of diabetics was compared with that in relatives of controls (K ratio), a method at present widely used to determine the mode of inheritance, a number of problems arose suggesting that this means of genetic analysis may be misleading in diseases such as diabetes. It is concluded, for reasons which are discussed, that differences in prevalence ratios cannot be accepted as good evidence for different modes of inheritance of younger- and older-onset diabetes in man." @default.
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- W11191547 date "1968-12-01" @default.
- W11191547 modified "2023-09-28" @default.
- W11191547 title "Age of onset and inheritance of diabetes: The importance of examining relatives" @default.
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- W11191547 doi "https://doi.org/10.1007/bf01211765" @default.
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