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- W111931381 abstract "ABSTRACT. Early mammalian development might be dependent in part on maternally transmitted storage products. One of these products, an enzyme lactate dehydrogenase, shows species differences with respect to its isozyme pattern in mammalian oocytes. In species of the orders Rodentia and Lagomorpha only LDH-1 (B-subunits) is demonstrable in the oocyte, while in species of the orders Carnivora and Artiodactyla and in man LDH isozymes formed of A and B-subunits are present in the oocyte. In the rabbit the LDH isozyme pattern changes during oocyte maturation. Oocytes in the dictyotan stage exhibit only LDH-1, while those induced by HCG for proceeding further in the meiotic process change their LDH pattern: LDH isozymes formed of A- and B-subunits become visible after the HCG injection. The newly appearing LDH isozymes might be due to an inactive maternally transmitted storage product, not further characterized till now. Furthermore it its shown that in rodent species in general the total preimplantation LDH activity is based on the maternally transmitted B-subunits while the activation of the embryonic LDH genes starts only with implantation." @default.
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- W111931381 date "1975-01-01" @default.
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- W111931381 title "ISOZYMES AS GENETIC MARKERS IN EARLY MAMMALIAN DEVELOPMENT" @default.
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- W111931381 doi "https://doi.org/10.1016/b978-0-12-472703-8.50012-3" @default.
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