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- W1119491617 abstract "Alveolar hypoxia, not increased pulmonary artery pressure, causes increased blood flow through intrapulmonary arteriovenous anastomoses (QIPAVA) in humans. However, it is unknown whether the hypoxic stimulus for QIPAVA is decreased arterial PO2 (PaO2) or arterial O2 content (CaO2). CaO2 is known to regulate blood flow in the systemic circulation and it is suggested that QIPAVA is regulated similar to the systemic vasculature. Thus, we hypothesized that reduced CaO2 would be the stimulus for hypoxia-induced QIPAVA. Blood volume (BV) was measured using the optimized carbon monoxide rebreathing method in 8 healthy subjects, 1 female. Less than 5 days later subjects breathed 18%, 14%, and 12.5% O2 for 30 min each, in a randomized order, before and after isovolemic hemodilution (IH; 10% of BV withdrawn and replaced with an equal volume of 5% human serum albumin). PaO2 was obtained at the end of each trial and QIPAVA was assessed using saline contrast echocardiography. Hemoglobin concentration was reduced from 14.2 ± 0.7 to 12.8 ± 0.5 g/dL with IH. PaO2 did not change pre- and post-IH at any FIO2, but CaO2 was 10.1, 11.3, and 5.4% lower at 18, 14, and 12.5% O2, respectively. QIPAVA was significantly increased as PaO2 decreased and despite reduced CaO2, was similar at iso-PO2. These data suggest that with alveolar hypoxia, low PaO2 causes the hypoxia-induced increase in QIPAVA. Support: Department of Defense" @default.
- W1119491617 created "2016-06-24" @default.
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- W1119491617 date "2015-04-01" @default.
- W1119491617 modified "2023-09-26" @default.
- W1119491617 title "Decreased Arterial PO 2 , not O 2 Content, Increases Blood Flow Through Intrapulmonary Arteriovenous Anastomoses at Rest" @default.
- W1119491617 doi "https://doi.org/10.1096/fasebj.29.1_supplement.1031.1" @default.
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