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- W1119784751 abstract "1124 Objectives To quantify the αvβ3 receptor expression on tumor-induced neovasculature with 111In-DOTA-E-[c(RGDfK)]2 using NanoSPECT/CT and Western blot during Taxol treatment. Methods Groups of nude mice(n=4~5 per time point) implanted s.c. with A431/K5 tumor cells, which do not express αvβ3, were treated with Taxol i.p. at 50mg/kg once on day 0 or twice on days 0 and 3. The tumor size was ~130 mm3 on day 0. The animals were euthanized on days 1, 4, and 7. The tumors were subjected to Western blot for the assessment of the receptor concentration. The mice also received i.v.111In-DOTA-E-[c(RGDfK)]2(300μCi/0.829μg) on day 4 and the imaging was performed at 2h post-injection using NanoSPECT/CT. Results A single dose with Taxol stopped the tumor growth for 4 days, thereafter the tumor started rebounding, and the tumor size doubled at day 7. The Western blot data showed that when treated with a single dose of Taxol, the β3 concentration decreased by 57% on day 1 but increased by 106% on day 4, and then returned back to the level of the control on day 7. With the second dose of Taxol on day 3, the increased receptor concentration on day 4 returned closer to the level in control tumor, reconfirming that Taxol treatment decreases the receptor concentration one day after the treatment. These findings were supported by the VOI analysis of the NanoSPECT/CT images on day 4: The single Taxol increased the tumor uptake(%ID/ml) by 68% on day 4 but the second dose of Taxol decreased the uptake to the control level. Conclusions There was a positive correlation between the tumor uptake of 111In-DOTA-E-[c(RGDfK)]2 determined by NanoSPECT/CT and previous biodistribution studies and the receptor concentration determined by Western blot. A drastic increase in the receptor concentration in neovasculature preceded a couple of days prior to rebounding of tumor growth, indicating that the changes in the receptor concentration could be used as a sensitive biomarker for the therapeutic response" @default.
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- W1119784751 date "2012-05-01" @default.
- W1119784751 modified "2023-09-24" @default.
- W1119784751 title "Investigation on changes in integrin αvβ3 expression on neovasculature as a surrogate marker of therapeutic response" @default.
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