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- W111979537 abstract "ABSTRACT Variants of a murine T-lymphoblastoid cell line (EL4) differing in their production of murine leukemia virus (MuLV) and in their expression of MuLV gene products at the cell surface, have similar morphological, growth and size characteristics, and express similar amounts of the normal T-cell surface differentiation alloantigen Thy-1. However, gene products of the H-2K and H-2D regions of the major histocompatibility complex (MHC) are present on the surface of the productively infected variant at a level approximately ten times that of the non-producing variant. Altering expression of H-2 products on the non-producing variant by infection with vesicular stomatitis virus (VSV), resulted in a concomitant and selective decrease in the expression of both H-2K and H-2D region products. VSV-infection of the MuLV producer line, however, resulted only in a modest decrease in H-2K antigen expression, with no effect on H-2D antigen expression. These results indicate possible differences between the two variant lines in cellular processing of H-2 antigens, and further suggest that H-2K and H-2D region products differ in their susceptibility to virus-induced alterations of surface expression in cells productively infected with MuLV." @default.
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- W111979537 date "1979-01-01" @default.
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- W111979537 title "ALTERED EXPRESSION OF T-LYMPHOID CELL SURFACE ANTIGENS ASSOCIATED WITH VIRAL INFECTION" @default.
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- W111979537 doi "https://doi.org/10.1016/b978-0-12-069850-9.50057-2" @default.
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