FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1120935590> ?p ?o ?g. }

• W1120935590 endingPage "257" @default.
• W1120935590 startingPage "248" @default.
• W1120935590 abstract "Psoriasis is one of the most common skin disorders characterized by erythematous plaques that result from hyperproliferative keratinocytes and infiltration of inflammatory leukocytes into dermis and epidermis. Recent studies suggest that IL-23/IL-17A/IL-22 cytokine axis plays an important role in the pathogenesis of psoriasis. The small molecule bromodomain and extraterminal domain (BET) inhibitors, that disrupt interaction of BET proteins with acetylated histones have recently demonstrated efficacy in various models of inflammation through suppression of several pathways, one of them being synthesis of IL-17A/IL-22 which primarily depends on transcription factor, retinoic acid receptor-related orphan receptor C (RORC). However, the efficacy and mechanistic aspect of a BET inhibitor in mouse model of skin inflammation has not been explored previously. Therefore, this study investigated the role of BET inhibitor, JQ-1 in mouse model of psoriasis-like inflammation. Mice were topically applied imiquimod (IMQ) to develop psoriasis-like inflammation on the shaved back and ear followed by assessment of skin inflammation (myeloperoxidase activity, ear thickness, and histopathology), RORC and its signature cytokines (IL-17A/IL-22). JQ-1 suppressed IMQ-induced skin inflammation as reflected by a decrease in ear thickness/myeloperoxidase activity, and RORC/IL-17A/IL-22 expression. Additionally, a RORα/γ agonist SR1078 was utilized to investigate the role of RORC in BET-mediated skin inflammation. SR1078 reversed the protective effect of JQ-1 on skin inflammation at both histological and molecular levels in the IMQ model. The current study suggests that BET bromodomains are involved in psoriasis-like inflammation through induction of RORC/IL-17A pathway. Therefore, inhibition of BET bromodomains may provide a new therapy against skin inflammation." @default.
• W1120935590 created "2016-06-24" @default.
• W1120935590 creator A5007163670 @default.
• W1120935590 creator A5027744482 @default.
• W1120935590 creator A5028281135 @default.
• W1120935590 creator A5031572027 @default.
• W1120935590 creator A5034517207 @default.
• W1120935590 creator A5041196844 @default.
• W1120935590 creator A5059999949 @default.
• W1120935590 creator A5061296890 @default.
• W1120935590 creator A5065620055 @default.
• W1120935590 creator A5074230436 @default.
• W1120935590 creator A5075640264 @default.
• W1120935590 date "2015-09-01" @default.
• W1120935590 modified "2023-09-30" @default.
• W1120935590 title "Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation" @default.
• W1120935590 cites W1505833426 @default.
• W1120935590 cites W1635215145 @default.
• W1120935590 cites W1939997832 @default.
• W1120935590 cites W1965692362 @default.
• W1120935590 cites W1982085112 @default.
• W1120935590 cites W1984164650 @default.
• W1120935590 cites W1987784314 @default.
• W1120935590 cites W2003872705 @default.
• W1120935590 cites W2005428052 @default.
• W1120935590 cites W2006731820 @default.
• W1120935590 cites W2012097026 @default.
• W1120935590 cites W2020358486 @default.
• W1120935590 cites W2033912854 @default.
• W1120935590 cites W2041535798 @default.
• W1120935590 cites W2057460011 @default.
• W1120935590 cites W2058487327 @default.
• W1120935590 cites W2067791830 @default.
• W1120935590 cites W2070176689 @default.
• W1120935590 cites W2071843884 @default.
• W1120935590 cites W2073037264 @default.
• W1120935590 cites W2079598877 @default.
• W1120935590 cites W2080705760 @default.
• W1120935590 cites W2081482161 @default.
• W1120935590 cites W2103600875 @default.
• W1120935590 cites W2107277218 @default.
• W1120935590 cites W2115908495 @default.
• W1120935590 cites W2120572492 @default.
• W1120935590 cites W2126818426 @default.
• W1120935590 cites W2127834887 @default.
• W1120935590 cites W2136940618 @default.
• W1120935590 cites W2142017607 @default.
• W1120935590 cites W2143549467 @default.
• W1120935590 cites W2143716911 @default.
• W1120935590 cites W2145634436 @default.
• W1120935590 cites W2150469988 @default.
• W1120935590 cites W2155582127 @default.
• W1120935590 cites W2561759163 @default.
• W1120935590 cites W4233561050 @default.
• W1120935590 doi "https://doi.org/10.1016/j.phrs.2015.06.001" @default.
• W1120935590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26149470" @default.
• W1120935590 hasPublicationYear "2015" @default.
• W1120935590 type Work @default.
• W1120935590 sameAs 1120935590 @default.
• W1120935590 citedByCount "88" @default.
• W1120935590 countsByYear W11209355902016 @default.
• W1120935590 countsByYear W11209355902017 @default.
• W1120935590 countsByYear W11209355902018 @default.
• W1120935590 countsByYear W11209355902019 @default.
• W1120935590 countsByYear W11209355902020 @default.
• W1120935590 countsByYear W11209355902021 @default.
• W1120935590 countsByYear W11209355902022 @default.
• W1120935590 countsByYear W11209355902023 @default.
• W1120935590 crossrefType "journal-article" @default.
• W1120935590 hasAuthorship W1120935590A5007163670 @default.
• W1120935590 hasAuthorship W1120935590A5027744482 @default.
• W1120935590 hasAuthorship W1120935590A5028281135 @default.
• W1120935590 hasAuthorship W1120935590A5031572027 @default.
• W1120935590 hasAuthorship W1120935590A5034517207 @default.
• W1120935590 hasAuthorship W1120935590A5041196844 @default.
• W1120935590 hasAuthorship W1120935590A5059999949 @default.
• W1120935590 hasAuthorship W1120935590A5061296890 @default.
• W1120935590 hasAuthorship W1120935590A5065620055 @default.
• W1120935590 hasAuthorship W1120935590A5074230436 @default.
• W1120935590 hasAuthorship W1120935590A5075640264 @default.
• W1120935590 hasConcept C104317684 @default.
• W1120935590 hasConcept C142724271 @default.
• W1120935590 hasConcept C164027704 @default.
• W1120935590 hasConcept C185592680 @default.
• W1120935590 hasConcept C203014093 @default.
• W1120935590 hasConcept C2776914184 @default.
• W1120935590 hasConcept C2777624698 @default.
• W1120935590 hasConcept C2779112978 @default.
• W1120935590 hasConcept C2779161069 @default.
• W1120935590 hasConcept C2779727006 @default.
• W1120935590 hasConcept C2780564577 @default.
• W1120935590 hasConcept C41091548 @default.
• W1120935590 hasConcept C502942594 @default.
• W1120935590 hasConcept C55493867 @default.
• W1120935590 hasConcept C71924100 @default.
• W1120935590 hasConcept C74401373 @default.
• W1120935590 hasConcept C74737994 @default.
• W1120935590 hasConcept C86339819 @default.

• next