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- W1122040679 abstract "Free radicals derived from nitrogen and oxygen have been found to have a significant role in physiological and pathophysiological processes. Originally, free radicals were believed to be associated exclusively with cellular damage. Free radicals are now widely implicated in cellular signaling, a fact that attacks the classic notion of biological mediators utilizing receptor-ligand interactions in a “lock and key” manner. Free-radical signaling is mainly based on redox chemistry, a unique mode of signal transduction. Nitric oxide is synthesized in most tissues, is diffusible, and can take on several chemical forms, each of which has its own reactive specificity. The major chemical modification produced by these species is nitrosation of the target, generally a protein iron or thiol. The direct interaction of nitric oxide with the protein target may result in either activation, inactivation, or switching of protein function and subsequent modulation of gene expression. Some physiological events regulated by this type of signaling include vasodilation, cytotoxicity, inflammation, and synaptic plasticity. Reactive oxygen species aid in propagating signals triggered by growth factors, hormones, and cytokines. This chapter attempts to explain the mechanistic basis of cell signaling by nitrogen- and oxygen-derived chemical species, and discusses their cellular targets and the physiological events they regulate." @default.
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- W1122040679 date "2000-01-01" @default.
- W1122040679 modified "2023-09-26" @default.
- W1122040679 title "Role of Nitric Oxide and Other Radicals in Signal Transduction" @default.
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- W1122040679 doi "https://doi.org/10.1016/b978-012370420-7/50017-4" @default.
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