Matches in SemOpenAlex for { <https://semopenalex.org/work/W112273437> ?p ?o ?g. }
- W112273437 endingPage "553" @default.
- W112273437 startingPage "543" @default.
- W112273437 abstract "Cure of leukemia by allogeneic haematopoietic cell transplantation (HCT) relies on the ability of the immune cells in the graft to recognize and eliminate the leukemia cells. The immunology of HCT is distinct from that of other types of transplant because, in addition to stem cells, the graft contains mature blood cells of donor origin, including T cells, natural killer (NK) cells and dendritic cells (DCs). These cells repopulate the recipient's lympho-haematopoietic system and give rise to a new immune system, which is pivotal in rebuilding immunity to infections and in eliminating residual leukemia cells that survived the conditioning regimen. This effect is known as the graft-versus-leukemia (GvL) effect. The donor immune system exerts its GvL effect through T cell–mediated alloreactions directed against recipient histocompatibility antigens displayed on recipient leukemia cells. This chapter illustrates the extraordinary progress at the crossroads of two diverse fields: allogeneic HCT and NK cell biology. The advent of haploidentical transplants made it possible to explore the role of NK cell allorecognition of missing self on KIR ligand mismatched allogeneic leukemia cells. In haploidentical and cord blood transplantation for AML, donor-versus-recipient-NK cell alloreactions impact beneficially on outcomes as they are associated with a strong GvL effect without increased risk of graft vs. host disease (GVHD). For almost all leukemia patients who fail to find a matched donor, whether related or unrelated, or a suitable cord blood unit, haematopoietic cell transplantation (HCT) from family donors who are matched for one human leukocyte antigen (HLA) haplotype and fully mismatched at the HLA class I and II loci of the unshared haplotype (“haploidentical”) is a viable option." @default.
- W112273437 created "2016-06-24" @default.
- W112273437 creator A5070029054 @default.
- W112273437 date "2010-01-01" @default.
- W112273437 modified "2023-09-25" @default.
- W112273437 title "Natural killer cells and allogeneic haematopoietic cell transplantation" @default.
- W112273437 cites W1481510475 @default.
- W112273437 cites W1500207187 @default.
- W112273437 cites W1508132320 @default.
- W112273437 cites W1595098530 @default.
- W112273437 cites W1603913234 @default.
- W112273437 cites W1895193514 @default.
- W112273437 cites W1911209830 @default.
- W112273437 cites W1963647603 @default.
- W112273437 cites W1967795348 @default.
- W112273437 cites W1968345966 @default.
- W112273437 cites W1969950463 @default.
- W112273437 cites W1969961365 @default.
- W112273437 cites W1976158721 @default.
- W112273437 cites W1987562611 @default.
- W112273437 cites W1989712520 @default.
- W112273437 cites W1993396723 @default.
- W112273437 cites W1993786192 @default.
- W112273437 cites W1994232628 @default.
- W112273437 cites W2006017701 @default.
- W112273437 cites W2006602967 @default.
- W112273437 cites W2008919922 @default.
- W112273437 cites W2008992933 @default.
- W112273437 cites W2016609860 @default.
- W112273437 cites W2017225287 @default.
- W112273437 cites W2018492618 @default.
- W112273437 cites W2020181553 @default.
- W112273437 cites W2023370541 @default.
- W112273437 cites W2024366773 @default.
- W112273437 cites W2025441450 @default.
- W112273437 cites W2027142061 @default.
- W112273437 cites W2027315624 @default.
- W112273437 cites W2030019925 @default.
- W112273437 cites W2032292023 @default.
- W112273437 cites W2034315146 @default.
- W112273437 cites W2037057992 @default.
- W112273437 cites W2037763524 @default.
- W112273437 cites W2039638023 @default.
- W112273437 cites W2044835282 @default.
- W112273437 cites W2048452843 @default.
- W112273437 cites W2049231401 @default.
- W112273437 cites W2057781614 @default.
- W112273437 cites W2058949406 @default.
- W112273437 cites W2062581776 @default.
- W112273437 cites W2066269914 @default.
- W112273437 cites W2074007150 @default.
- W112273437 cites W2074165388 @default.
- W112273437 cites W2074280192 @default.
- W112273437 cites W2075244013 @default.
- W112273437 cites W2076118435 @default.
- W112273437 cites W2076345221 @default.
- W112273437 cites W2078808543 @default.
- W112273437 cites W2079241332 @default.
- W112273437 cites W2079786360 @default.
- W112273437 cites W2080826082 @default.
- W112273437 cites W2084292672 @default.
- W112273437 cites W2086865864 @default.
- W112273437 cites W2087576224 @default.
- W112273437 cites W2098130458 @default.
- W112273437 cites W2098697457 @default.
- W112273437 cites W2109176206 @default.
- W112273437 cites W2116693169 @default.
- W112273437 cites W2122739582 @default.
- W112273437 cites W2122941510 @default.
- W112273437 cites W2124475984 @default.
- W112273437 cites W2132268212 @default.
- W112273437 cites W2133109711 @default.
- W112273437 cites W2133184513 @default.
- W112273437 cites W2134872632 @default.
- W112273437 cites W2137698660 @default.
- W112273437 cites W2138781831 @default.
- W112273437 cites W2147068163 @default.
- W112273437 cites W2154518608 @default.
- W112273437 cites W2155690142 @default.
- W112273437 cites W2164296311 @default.
- W112273437 cites W2165093569 @default.
- W112273437 cites W2165920713 @default.
- W112273437 cites W2170069789 @default.
- W112273437 cites W2171160333 @default.
- W112273437 cites W2171709048 @default.
- W112273437 cites W35202944 @default.
- W112273437 doi "https://doi.org/10.1016/b978-0-12-370454-2.00042-9" @default.
- W112273437 hasPublicationYear "2010" @default.
- W112273437 type Work @default.
- W112273437 sameAs 112273437 @default.
- W112273437 citedByCount "1" @default.
- W112273437 countsByYear W1122734372012 @default.
- W112273437 crossrefType "book-chapter" @default.
- W112273437 hasAuthorship W112273437A5070029054 @default.
- W112273437 hasConcept C109159458 @default.
- W112273437 hasConcept C126322002 @default.
- W112273437 hasConcept C147483822 @default.
- W112273437 hasConcept C188280979 @default.