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- W11230068 abstract "Agatoxin-489, extracted from the venom of the Agelenopsis aperta spider, was studied on acutely isolated perfused hippocampal neurons of rat using the concentration clamp technique. Agatoxin-489 proved to be a selective N-methyl-d-aspartate antagonist; responses to applications of N-methyl-d-aspartate or l-aspartate were blocked by concentrations of agatoxin-489 ranging between 0.1 nM and 1 μM, while responses to kainate were not affected by agatoxin-489 at concentrations up to 10μM. The actions of agatoxin-489 against responses to N-methyl-d-aspartate or l-aspartate were use- and voltage-dependent, being less pronounced with an increase in the holding potential from —100 to —30 mV. The action of agatoxin-489 could be completely or partially reversed only after washout in the presence of an N-methyl-d-aspartate agonist. The washout was more effective at positive membrane potentials ranging from 0 to +20mV. These results imply that the spider toxin agatoxin-489, like dizocilpine, is a potent and selective N-methyl-d-aspartate antagonist which preferentially interacts with activated N-methyl-d-aspartate receptors and/or open N-methyl-d-aspartate-activated ionic channels." @default.
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- W11230068 date "1992-11-01" @default.
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- W11230068 title "A highly potent and selective receptor antagonist from the venom of the Agelenopsis aperta spider" @default.
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- W11230068 doi "https://doi.org/10.1016/0306-4522(92)90465-e" @default.
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