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- W112319575 abstract "The authors have examined pH gradient-driven Na{sup +} uptake and Na{sup +}-driven H{sup +} transport in brush-border membrane vesicles prepared from jejunal tissue obtained from organ donors by measuring the influx of {sup 22}Na and the fluorescence quenching of acridine orange (AO). Vesicle preparation by either Ca{sup 2+} or Mg{sup 2+} precipitation showed no difference in {sup 22}Na uptake or AO fluorescence quenching and dissipation. An outward H{sup +} gradient induced a Na{sup +} uptake overshoot of threefold over equilibrium, whereas the absence of an H{sup +} gradient did not produce an overshoot. The initial rate of pH-driven Na{sup +} uptake in voltage-clamped vesicles was related to (Na{sup +}{sub o}). Amiloride inhibited this uptake in voltage-clamped vesicles. Dissipation of AO fluorescence quench in vesicles with a preformed internal acid gradient was hastened by Na{sup +}{sub o} as well as voltage clamping in the absence of Na{sup +}. In vesicles without a pH gradient, internal Na{sup +}, as well as a diffusion potential in the absence of Na{sup +}, induced AO quenching. External Na{sup +} and Li{sup +}, but not choline, acted to dissipate AO quenching induced by a diffusion potential, and the rate of dissipation was unaffected by the presencemore » of Cl{sup {minus}}. Li{sup +} and NH{sup +}{sub 4}, but not Cs{sup +}, K{sup +}, Rb{sup +}, or choline{sup +}, inhibited pH gradient-driven {sup 22}Na uptake. They conclude that human jejunal brush-border membrane vesicles contain conductive pathways for both Na{sup +} and H{sup +} and an Na{sup +}-H{sup +} exchanger.« less" @default.
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- W112319575 date "1988-08-01" @default.
- W112319575 modified "2023-09-26" @default.
- W112319575 title "Na sup + and H sup + transport in human jejunal brush-border membrane vesicles" @default.
- W112319575 hasPublicationYear "1988" @default.
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