Matches in SemOpenAlex for { <https://semopenalex.org/work/W1124018604> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1124018604 abstract "We reported that brain (pro)renin receptor (PRR) expression is elevated in deoxycorticosterone acetate (DOCA)-salt hypertension; however, the underlining mechanism remains unknown. To test our hypothesis that epigenetic mechanism is involved in the regulation of PRR expression in DOCA-salt hypertension, C57Bl/6J mice were implanted with SHAM or DOCA pellet and supplied with saline for 3 weeks. Histone modifications on PRR promoter were assessed in the hypothalamus using Chromatin Immunoprecipitation assays at the end of protocol. We found an increase (fold change) in histone 3 lysine 4 trimethylation (H3K4me3) on the PRR promoter in DOCA-salt (2.45±0.36) compared with SHAM treated mice (1.00±0.16, P<0.05), which was not altered by ICV infusion of losartan (2.33±0.27). Importantly, we found increased H3K4 methyltransferases (HMT) activity (OD/hour/mg protein), an enzyme complex responsible for H3K4 methylation, after DOCA-salt treatment (44.54±2.09, P<0.05) compared with SHAM (28.23±2.05). To examine the contribution of H3K4me3 on PRR expression and the increased BP during DOCA-salt hypertension, mice were treated with DOCA-salt and ICV infused with either artificial CSF or 5'-methylthioadenosine (MTA), a specific methyltransferase inhibitor, for 3 weeks. ICV infusion of MTA normalized the increase in H3K4me3 (0.9±0.11), HMT activity (32.3±2.38) compared with ICV aCSF in DOCA-salt treated mice. ICV infusion of MTA attenuated PRR mRNA levels (1.4±0.1 vs. 2.4±0.2) and BP (123.1±6.3 vs. 138.5±7.4 mmHg) compared with control following DOCA-salt treatment. In summary, H3K4me3 on PRR promoter is a key epigenetic mechanism for the up-regulation of brain PRR and the increase in BP during salt-sensitive hypertension." @default.
- W1124018604 created "2016-06-24" @default.
- W1124018604 creator A5042147723 @default.
- W1124018604 creator A5044239371 @default.
- W1124018604 creator A5081036799 @default.
- W1124018604 date "2015-04-01" @default.
- W1124018604 modified "2023-09-26" @default.
- W1124018604 title "Trimethylation of Histone 3 Lysine 4 on Hypothalamic (Pro)renin Receptor Mediates the Development of DOCA‐salt Hypertension." @default.
- W1124018604 doi "https://doi.org/10.1096/fasebj.29.1_supplement.984.2" @default.
- W1124018604 hasPublicationYear "2015" @default.
- W1124018604 type Work @default.
- W1124018604 sameAs 1124018604 @default.
- W1124018604 citedByCount "0" @default.
- W1124018604 crossrefType "journal-article" @default.
- W1124018604 hasAuthorship W1124018604A5042147723 @default.
- W1124018604 hasAuthorship W1124018604A5044239371 @default.
- W1124018604 hasAuthorship W1124018604A5081036799 @default.
- W1124018604 hasConcept C126322002 @default.
- W1124018604 hasConcept C134018914 @default.
- W1124018604 hasConcept C170493617 @default.
- W1124018604 hasConcept C185592680 @default.
- W1124018604 hasConcept C198710026 @default.
- W1124018604 hasConcept C2776016237 @default.
- W1124018604 hasConcept C515207424 @default.
- W1124018604 hasConcept C552990157 @default.
- W1124018604 hasConcept C55493867 @default.
- W1124018604 hasConcept C64927066 @default.
- W1124018604 hasConcept C71924100 @default.
- W1124018604 hasConcept C84393581 @default.
- W1124018604 hasConcept C86803240 @default.
- W1124018604 hasConcept C95444343 @default.
- W1124018604 hasConcept C98274493 @default.
- W1124018604 hasConceptScore W1124018604C126322002 @default.
- W1124018604 hasConceptScore W1124018604C134018914 @default.
- W1124018604 hasConceptScore W1124018604C170493617 @default.
- W1124018604 hasConceptScore W1124018604C185592680 @default.
- W1124018604 hasConceptScore W1124018604C198710026 @default.
- W1124018604 hasConceptScore W1124018604C2776016237 @default.
- W1124018604 hasConceptScore W1124018604C515207424 @default.
- W1124018604 hasConceptScore W1124018604C552990157 @default.
- W1124018604 hasConceptScore W1124018604C55493867 @default.
- W1124018604 hasConceptScore W1124018604C64927066 @default.
- W1124018604 hasConceptScore W1124018604C71924100 @default.
- W1124018604 hasConceptScore W1124018604C84393581 @default.
- W1124018604 hasConceptScore W1124018604C86803240 @default.
- W1124018604 hasConceptScore W1124018604C95444343 @default.
- W1124018604 hasConceptScore W1124018604C98274493 @default.
- W1124018604 hasIssue "S1" @default.
- W1124018604 hasLocation W11240186041 @default.
- W1124018604 hasOpenAccess W1124018604 @default.
- W1124018604 hasPrimaryLocation W11240186041 @default.
- W1124018604 hasRelatedWork W2034583712 @default.
- W1124018604 hasRelatedWork W2044747643 @default.
- W1124018604 hasRelatedWork W2047608102 @default.
- W1124018604 hasRelatedWork W2063619316 @default.
- W1124018604 hasRelatedWork W2074821979 @default.
- W1124018604 hasRelatedWork W2077998387 @default.
- W1124018604 hasRelatedWork W2126797993 @default.
- W1124018604 hasRelatedWork W2149410839 @default.
- W1124018604 hasRelatedWork W2162471541 @default.
- W1124018604 hasRelatedWork W2169225653 @default.
- W1124018604 hasVolume "29" @default.
- W1124018604 isParatext "false" @default.
- W1124018604 isRetracted "false" @default.
- W1124018604 magId "1124018604" @default.
- W1124018604 workType "article" @default.