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- W112482003 abstract "The antigonadotropic antiandrogenic and androgenic estrogenic antiestrogenic progestational and antiprogestational activities of Danazol were investigated in rats mice and rabbits. Injection of Danazol to hemicastrated or intact male or female rats led to a suppression of gonadal growth development and steroidogenesis which could be reversed by the administration of exogenous gonadotropins. There was no evidence of competitive inhibition of the exogenous gonadotropins. The above effects were significant at a dosage of 4 mg/kg. In immature rabbits dosages of 10 and 40 mg/kg led to secretory-like changes of the proliferative endometrium. There were no definite progestational or antiprogestational effects observed. The compound demonstrated a weak mytrophic effect as judged by the weight of musculus levator ani." @default.
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- W112482003 date "1971-01-01" @default.
- W112482003 modified "2023-10-18" @default.
- W112482003 title "Danazol—a Synthetic Steroid Derivative with Interesting Physiologic Properties " @default.
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- W112482003 doi "https://doi.org/10.1016/s0015-0282(16)37981-x" @default.
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