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- W112486615 abstract "The evolution of the immune system has provided a multilevel system that interconnects the innate and adaptive immune systems to serve at least three central purposes: the defense from microbial pathogens, the capacity for discrimination of self- from non-self necessary for the prevention of autoimmune disease, and essential effector roles in wound repair and tissue remodeling. In recent studies, we have elucidated an unsuspected role for a class of naturally occurring autoreactive antibodies from the most primitive tier of B lymphocytes, which regulates fundamental functions of the innate immune system. Our findings also throw light onto long unresolved mysteries regarding the origins of the earliest waves of B lymphocyte development." @default.
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- W112486615 date "2009-10-01" @default.
- W112486615 modified "2023-09-23" @default.
- W112486615 title "Natural autoantibodies to apoptotic cell membranes regulate fundamental innate immune functions and suppress inflammation." @default.
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