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- W1125845557 abstract "目的：探讨GPⅡb/Ⅲa 拮抗剂RGDS和钙通道拮抗剂Nifedipine对ADP诱导的血小板GPⅡb/Ⅲa活化的影响。方法GP II b／11I a特异性抗体PAC-1标记活化GP II b／11I a，流式细胞仪检测静息及 ADP（5μmol/L）诱导的血小板PAC-1表达率。结果静息状态下的血小板PAC-1表达率为（0.80±0.85）％；在ADP（5μmol/L）激动下，PAC-1表达率为（77.27±9.47）%；RGDS以浓度依赖性的方式抑制PAC-1表达率，IC50值为206μmol/L；Nifedipine能以浓度依赖性的方式抑制PAC-1表达率，IC50值为178μmol/L；RGDS联合Nifedipine对PAC-1表达的联合抑制率为（60.15±16.35）％，二者的交互效应差异有统计学意义（P〈0.05）。结论GPIIb/IIIa受体拮抗剂RGDS和Ca2＋拮抗剂Nifedipine均抑制ADP诱导的血小板GPIIb/IIIa活化，其抑制作用呈浓度依赖性，随拮抗剂浓度增加抑制作用增强；两者对血小板GPIIb/IIIa活化的抑制存在协同作用。" @default.
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- W1125845557 date "2014-01-01" @default.
- W1125845557 modified "2023-09-23" @default.
- W1125845557 title "血小板GPIIb/IIIa拮抗剂RGDS和钙通道拮抗剂Nifedipine对GPIIb/IIIa活化的影响" @default.
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