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- W112586429 abstract "The function of the immune response is to protect an organism from foreign material by first recognizing the material as foreign and then activating a cascade of events that leads to its removal. To perform this function without damaging the host, the immune system must distinguish between self and nonself, and target removal mechanisms only toward nonself antigens. The ability of the immune system to not respond to certain antigens (particularly self antigens) is an active process that is called tolerance. Tolerance is maintained by at least two processes: a system of lymphocyte “education” in the thymus and ongoing regulation of immune activation throughout life. When tolerance is lost or “broken,” the immune system recognizes self antigens as foreign and tries to remove them by initiating the inflammatory cascade. It is this inflammatory process, directed against self, that causes the tissue damage and clinical features of autoimmune disease." @default.
- W112586429 created "2016-06-24" @default.
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- W112586429 date "2000-01-01" @default.
- W112586429 modified "2023-09-23" @default.
- W112586429 title "Restoration of Immune Tolerance" @default.
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- W112586429 doi "https://doi.org/10.1007/978-1-59259-018-6_32" @default.
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