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- W1126030258 abstract "Piper betel, Solanum nigrum and Zingiber cassumunar have been used among Malaycommunity in traditional medicine for curing many diseases. These plants are believedto protect the mucosal lining of the stomach from ulcerogens. This study wasconducted to investigate the antiulcerogenic properties of ethanol extracts of theseplants. One hundred and forty four Sprague Dawley rats were used in this study. Therats were divided into two major groups, the control and treatment group. There were 6groups of control rats (normal saline (Al); ethanol (Bl); aspirin (Cl); acetic acid (Dl);indomethacin (El); and cimetidine (Fl)). All control groups received distilled water adlibitum 7 days and fasted 24 hours prior forced fed either with normal saline, ethanol,aspirin, acetic acid, indomethacin and cimetidine accordingly. Treated groups weregiven 2mg / lOOg body weight per day of Piper betel, Solanum nigrum and Zingibercassumunar extract for 7 days, fasted 24 hours prior force fed with either normal saline(Group A2, A3, A4); ethanol (Group B2, B3, B4); aspirin (Group C2, C3, C4); aceticacid (Group D2, D3, D4); indomethacin (Group E2, E3, E4) or cimetidine (Group F2,F3, F4) accordingly. They were 18 groups all together. They were then fasted again for24 hours before sacrificed. Macroscopically, the stomachs of rats treated with all plantextracts of all ulcerogen groups (B2, B3, B4; C2, C3, C4; D2, D3, D4; E2, E3, E4; F2,F3, F4) showed a reduced ulcers with significant different (p < 0.05) when compared toB1, C1, Dl and El control groups. Even though treated groups showed some edemaand small ulcers, they gave less lesion score when compared to B1, Cl, Dl and Elcontrol group. Histological findings showed reduced damage and inflammation scorewithout erosion of mucosal layer in groups treated with Piper betel, Solanum nigrumand Zingiber cassumunar when compared to B1, C1, Dl and El groups. Even thoughthere was slight epithelial disruptions, minimal inflammatory reactions and presence ofred blood cells, the damage and inflammation score were less and significantly reduced(p < 0.05) when compared to control groups. This present study suggests that Piperbetel, Solanum nigrum and Zingiber cassumunar have some beneficial propertiesimplying that they may have some protective mechanisms to protect stomach fromulcerogens." @default.
- W1126030258 created "2016-06-24" @default.
- W1126030258 creator A5010526601 @default.
- W1126030258 date "2005-04-01" @default.
- W1126030258 modified "2023-09-27" @default.
- W1126030258 title "Anti-Ulcer Effects of Piper Betel, Solanum Nigrum and Zingibercassumunar on Ulceration Induced by Selected Ulcerogens Inrats" @default.
- W1126030258 hasPublicationYear "2005" @default.
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