Matches in SemOpenAlex for { <https://semopenalex.org/work/W112674863> ?p ?o ?g. }
- W112674863 endingPage "CMT.S2133" @default.
- W112674863 startingPage "CMT.S2133" @default.
- W112674863 abstract "Ciclesonide is a novel inhaled corticosteroid (ICSs) approved in most countries for the management of persistent asthma. Although inhaled corticosteroids are first-line therapy in the treatment of asthma, long term use and high-doses of these products may result in significant side effects. When developing a new ICSs, the goal is to identify a drug with comparable (or superior) efficacy to active comparators, and an improved safety profile. Ciclesonide is a prodrug which is administered through a hydrofluoroalkane-propellant metered dose inhaler (HFA-MDI). Once it reaches the lungs, the parent compound is metabolized by esterases to desisobutyryl ciclesonide (des-CIC), an active metabolite with a 100-fold greater affinity for the glucocorticoid receptor. Ciclesonide has a unique pharmacokinetic-pharmacodynamic profile which confers an improved therapeutic ratio. Several clinical trials have shown that its efficacy is superior to placebo and similar to several active comparators. However, its high pulmonary deposition and on-site activation minimizes the risk for local side effects. Also, its low oral bioavailability, high hepatic clearance, and extensive plasma protein binding, among other factors, decrease the risk for systemic side effects. Doses of ciclesonide as high as 1280 μg/day (ex-actuator) result in minimal hypothalamic-pituitary-adrenal (HPA) axis suppression, a measure commonly used to assess systemic bioavailability for an ICSs. This review will provide a summary of ciclesonide's role in the management of asthma, including a discussion of relevant clinical trials designed to evaluate its efficacy and safety." @default.
- W112674863 created "2016-06-24" @default.
- W112674863 creator A5075015951 @default.
- W112674863 creator A5078634243 @default.
- W112674863 date "2009-01-01" @default.
- W112674863 modified "2023-09-23" @default.
- W112674863 title "Ciclesonide in the Management of Asthma" @default.
- W112674863 cites W1554562511 @default.
- W112674863 cites W1964657213 @default.
- W112674863 cites W1965677615 @default.
- W112674863 cites W1967989858 @default.
- W112674863 cites W1971058789 @default.
- W112674863 cites W1976341559 @default.
- W112674863 cites W1979181245 @default.
- W112674863 cites W1979797331 @default.
- W112674863 cites W1984247088 @default.
- W112674863 cites W1984622531 @default.
- W112674863 cites W1985265092 @default.
- W112674863 cites W1985579704 @default.
- W112674863 cites W1989183270 @default.
- W112674863 cites W1992170505 @default.
- W112674863 cites W1998462313 @default.
- W112674863 cites W1999540671 @default.
- W112674863 cites W2006499560 @default.
- W112674863 cites W2010818576 @default.
- W112674863 cites W2015988862 @default.
- W112674863 cites W2017939992 @default.
- W112674863 cites W2019259561 @default.
- W112674863 cites W2023638448 @default.
- W112674863 cites W2024458062 @default.
- W112674863 cites W2025126809 @default.
- W112674863 cites W2027001724 @default.
- W112674863 cites W2028477150 @default.
- W112674863 cites W2034414104 @default.
- W112674863 cites W2034545406 @default.
- W112674863 cites W2036904276 @default.
- W112674863 cites W2038418947 @default.
- W112674863 cites W2039230230 @default.
- W112674863 cites W2043012375 @default.
- W112674863 cites W2043162795 @default.
- W112674863 cites W2044629269 @default.
- W112674863 cites W2058526726 @default.
- W112674863 cites W2060635084 @default.
- W112674863 cites W2065138654 @default.
- W112674863 cites W2067489082 @default.
- W112674863 cites W2068523761 @default.
- W112674863 cites W2072173344 @default.
- W112674863 cites W2073100929 @default.
- W112674863 cites W2081776165 @default.
- W112674863 cites W2086038621 @default.
- W112674863 cites W2090555292 @default.
- W112674863 cites W2091056531 @default.
- W112674863 cites W2091091085 @default.
- W112674863 cites W2098680476 @default.
- W112674863 cites W2098826581 @default.
- W112674863 cites W2099379311 @default.
- W112674863 cites W2099818893 @default.
- W112674863 cites W2107107374 @default.
- W112674863 cites W2110005263 @default.
- W112674863 cites W2116854018 @default.
- W112674863 cites W2116894140 @default.
- W112674863 cites W2117867745 @default.
- W112674863 cites W2118514058 @default.
- W112674863 cites W2119869146 @default.
- W112674863 cites W2123078357 @default.
- W112674863 cites W2133535584 @default.
- W112674863 cites W2133689587 @default.
- W112674863 cites W2139148381 @default.
- W112674863 cites W2141527237 @default.
- W112674863 cites W2147251547 @default.
- W112674863 cites W2149383913 @default.
- W112674863 cites W2151676573 @default.
- W112674863 cites W2152587755 @default.
- W112674863 cites W2154299860 @default.
- W112674863 cites W2154942700 @default.
- W112674863 cites W2159019899 @default.
- W112674863 cites W2165693078 @default.
- W112674863 cites W2170576139 @default.
- W112674863 cites W2171335767 @default.
- W112674863 cites W2320103243 @default.
- W112674863 cites W4249152248 @default.
- W112674863 doi "https://doi.org/10.4137/cmt.s2133" @default.
- W112674863 hasPublicationYear "2009" @default.
- W112674863 type Work @default.
- W112674863 sameAs 112674863 @default.
- W112674863 citedByCount "1" @default.
- W112674863 countsByYear W1126748632023 @default.
- W112674863 crossrefType "journal-article" @default.
- W112674863 hasAuthorship W112674863A5075015951 @default.
- W112674863 hasAuthorship W112674863A5078634243 @default.
- W112674863 hasBestOaLocation W1126748631 @default.
- W112674863 hasConcept C108215921 @default.
- W112674863 hasConcept C111113717 @default.
- W112674863 hasConcept C112705442 @default.
- W112674863 hasConcept C126322002 @default.
- W112674863 hasConcept C142724271 @default.
- W112674863 hasConcept C149151106 @default.
- W112674863 hasConcept C181389837 @default.