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- W11268123 abstract "Abstract There are over 20,000 DNA sequences from human immunoglobulins represented in Genbank. This wealth of DNA sequence information provides an opportunity to study the structural correlates of immunoglobulin function, including autoreactivity and to infer molecular mechanism from statistical signatures. After careful control for removal of clonally related genes, we analyzed approximately 9,400 productively rearranged sequences in order to establish baseline statistical characteristics, such as gene segment usage, n-nucleotide and mutation frequency, and the biochemical properties of CDR regions. We then analyzed 181 autoreactive and 64 anti-DNA Ig sequences against this baseline to discern statistical differences that might distinguish structurally these functionally distinct genes. Our data reveal that there are indeed distinctive biases in gene segment usage, CDR3 length, and mutation frequency that differ from one group to another. We also fit data on n-nucleotide frequency to a negative binomial model, which reveals striking differences between the DJ and VD junctions. These results have an appealing interpretation in terms of differential access of terminal deoxynucleotidyl transferase in the developing junctions." @default.
- W11268123 created "2016-06-24" @default.
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- W11268123 date "2007-04-01" @default.
- W11268123 modified "2023-09-25" @default.
- W11268123 title "A Large-scale survey of human Ig Heavy Chain genes in Genbank: Structural Correlates of Autoreactivity and Statistical Signatures of Molecular Mechanisms (35.5)" @default.
- W11268123 doi "https://doi.org/10.4049/jimmunol.178.supp.35.5" @default.
- W11268123 hasPublicationYear "2007" @default.
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