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- W112707837 abstract "• Primary bone tumors are rare; non-neoplastic conditions, metastatic disease, and lymphohematologic malignancies, which may simulate primary bone tumors, by far outnumber genuine bone tumors. • Excluding myeloma and lymphoma, malignant primary bone tumors constitute only 0.2% of all malignancies in adults and approximately 5% of childhood malignancies. • Bone tumor classification is based on morphologic findings: cell type, architecture, and matrix production. The morphologic features of benign and malignant as well as non-neoplastic conditions and true tumors may overlap. • Many bone tumor entities show a striking consistency in clinical setting and age and anatomic site distribution. • The final diagnosis of bone tumors should be based on a synthesis of histopathologic findings, clinical presentation, and imaging characteristics, preferably in the setting of a multidisciplinary team conference. • Adjunctive immunohistochemical and genetic/molecular genetic techniques are important for the definite classification of certain bone tumors. • A number of congenital, hereditary, and nonhereditary syndromes are associated with increased risk of bone tumors." @default.
- W112707837 created "2016-06-24" @default.
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- W112707837 date "2009-01-01" @default.
- W112707837 modified "2023-09-23" @default.
- W112707837 title "Bone Tumors: Epidemiology, Classification, Pathology" @default.
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- W112707837 doi "https://doi.org/10.1007/978-3-540-77984-1_1" @default.
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