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- W1127264686 abstract "A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2 diabetes, without an appreciable activation of their brown adipose tissue. Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake." @default.
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- W1127264686 date "2015-07-06" @default.
- W1127264686 modified "2023-10-16" @default.
- W1127264686 title "Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus" @default.
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- W1127264686 doi "https://doi.org/10.1038/nm.3891" @default.
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