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- W1127518593 abstract "Objective To investigate the affect of Notoginsenoside R1 on human gastric cancer cells (SGC7901) and its relationship with precursor nerve growth factor (proNGF) signal pathway. Methods SGC-7901 was cultured in vitro and randomly divided into normal, control and experimental groups, and then, each group was divided into 24, 48 and 72 h groups. The experimental group cells were co-cultured with Notoginsenoside R1 at 2 mg/mL, but saline in control groups, and normal groups had no other treatment. After that,3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to detect the cell activity and terminal dexynucleotidyl transferase(TdT)-mediated dUTP nick end labeling (TUNEL) was used to detect the apoptosis of the cells. Immunofluorescence was used to locate proNGF, p75 and Sortilin expression, and the proNGF, p75 and Sortilin mRNA was detected by Real time Polymerase Chain Reaction (PCR), and Western Blotting was used to detect the protein expression. Results 1, SGC7901 was successfully cultured. 2, Cell viability in experimental groups was decreased compared with normal or control groups, but the apoptosis was increased. 3, proNGF, p75 and Sortilin mRNA or protein were up-regulated in experimental groups. Conclusion Notoginsenoside R1 can decrease the biological activity and increase the apoptosis of SGC7901, and the mechanism may be by increasing the expression of proNGF apoptosis signal pathway. * Corresponding author: Jian-hui Guo (guojianhuikm@163.com) and Li-yan Li (kmliyanl@163.com)" @default.
- W1127518593 created "2016-06-24" @default.
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- W1127518593 date "2015-04-01" @default.
- W1127518593 modified "2023-09-24" @default.
- W1127518593 title "Notoginsenoside R1 Promotes SGC7901 Apoptosis by Up‐regulating the ProNGF Signaling Pathway" @default.
- W1127518593 doi "https://doi.org/10.1096/fasebj.29.1_supplement.704.7" @default.
- W1127518593 hasPublicationYear "2015" @default.
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