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• W1127606598 abstract "Diabetes is a hereditary disease, but the nature of the genetic defect and its primary lesion are unknown. It involves a widespread disorder of metabolism, but exhaustive study has not yet determined whether this is a cause or consequence of the hormonal, vascular, and neurological abnormalities of the disease. The hypoglycemic drugs that are used today to treat well over a million diabetics are descended in a direct line from two essentially chance observations—that is, certain antibacterial sulfonamides caused hypoglycemia and that a simple guanidine derivative reduced the blood sugar of rabbits. In spite of the vast body of fact and conjecture now contained in the literature of diabetes, metabolic biochemistry, and the control of metabolism, no antidiabetic drug has yet come from the rational application of knowledge about these processes. Compounds unrelated to the sulfonylureas or guanidine derivatives have been studied for their hypoglycemic properties; all are apparently first identified by a largely empirical observation of their effect on blood sugar in experimental animals. This chapter briefly discusses diabetes as a disease entity and describes some of the hormonal factors and metabolic processes that are deranged in diabetes. It focuses on the relationship of these factors to the disease and provides a few leading references that may stimulate thought on possible new approaches to antidiabetic drugs." @default.
• W1127606598 created "2016-06-24" @default.
• W1127606598 creator A5030032617 @default.
• W1127606598 date "1966-01-01" @default.
• W1127606598 modified "2023-10-16" @default.
• W1127606598 title "Chapter 15. Antidiabetic Agents" @default.
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• W1127606598 doi "https://doi.org/10.1016/s0065-7743(08)60064-0" @default.
• W1127606598 hasPublicationYear "1966" @default.
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