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- W112779156 abstract "Serious disease caused by Streptococcus pyogenes (group A streptococcus, GAS), particularly rheumatic heart disease and invasive GAS infection, is responsible for more than half a million deaths worldwide per year. With no effective control strategies available for these diseases, a GAS vaccine is urgently needed. The development of a global GAS vaccine has been hindered by the large diversity of circulating strains ( emm- types) of GAS in low-incomes settings. While approximately 80% coverage of the common emm- types in the USA and in Europe is theoretically possible with the 26 emm- type vaccine, the coverage in low-income settings, where serious GAS disease is most common, would be as low as 30%. Recent in vitro and in silico discoveries offer an exciting new approach to developing vaccines that protect against the broad range of strains in different regions of the world. These data suggest that antibodies against some emm- types may cross-protect against other emm- types. Cross protection between emm- types would represent a new paradigm in our understanding of immunity against GAS and an avenue for future GAS vaccine formulations." @default.
- W112779156 created "2016-06-24" @default.
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- W112779156 date "2014-02-15" @default.
- W112779156 modified "2023-09-27" @default.
- W112779156 title "Immunity and vaccine development against Streptococcus pyogenes: is emm-typing enough?" @default.
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