FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W112830345> ?p ?o ?g. }

• W112830345 endingPage "58" @default.
• W112830345 startingPage "547" @default.
• W112830345 abstract "The authors previously reported that a diet containing 30% galactose retards the development of the late-onset photoreceptor dystrophy in the spontaneously hypertensive (SHR) rat. It was suggested that the dystrophy might result from faulty galactosylation of a critical glycoprotein or glycosaminoglycan (GAG) in the interphotoreceptor matrix (IPM). In the current study, this hypothesis was tested by studying IPM protein and GAG composition in SHR and normotensive Wistar-Kyoto (WKy) control strain rats fed a standard or a high-galactose (30%) diet.The authors performed biochemical analyses of the IPM of SHR and of WKy control rats fed either the basal diet or a 30% galactose diet for 14 mo and labeled at the termination of the experiment with 3H-glucosamine and 35S-sulfate. Analyses included high-performance liquid chromatography and two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and isoelectric focusing (IEF) of extracted proteoglycans with identification of the GAG by selective enzymatic degradation and immunoblotting of SDS-PAGE gels for interphotoreceptor retinol-binding protein (IRBP), with slot blots for additional quantitation.Although several differences were detected in GAG radiolabeling between the two strains, only one, a decreased overall synthesis of 3H-glucosamine-labeled GAG in the WKy rats, was altered by the high-galactose diet. There was no apparent difference in the protein patterns of the IPM as evaluated by two-dimensional SDS-PAGE and IEF. However, slot blots of that portion of the IPM extracted from the neural retinas showed less reactivity per microgram of protein for IRBP in the galactose-fed animals of both strains than for the rats fed a basal diet. This was statistically significant, however, only in the WKy rats.The composition of the IPM of these two strains of rat appears similar to the composition of the IPM of other species that have been studied. Whether the quantitative alteration in IRBP that appears to be produced by galactose feeding has functional significance, with particular relevance to retarding the development of the photoreceptor cell dystrophy of the SHR rat, is unclear at this time." @default.
• W112830345 created "2016-06-24" @default.
• W112830345 creator A5059487056 @default.
• W112830345 creator A5062234942 @default.
• W112830345 date "1993-03-01" @default.
• W112830345 modified "2023-09-23" @default.
• W112830345 title "Effects of a high-galactose diet on the interphotoreceptor matrix of two strains of rat." @default.
• W112830345 cites W1606423922 @default.
• W112830345 cites W1972385335 @default.
• W112830345 cites W1973116123 @default.
• W112830345 cites W1987834587 @default.
• W112830345 cites W2028803712 @default.
• W112830345 cites W2034704277 @default.
• W112830345 cites W2046673437 @default.
• W112830345 cites W2081173855 @default.
• W112830345 cites W2083062636 @default.
• W112830345 cites W2100837269 @default.
• W112830345 cites W2101108802 @default.
• W112830345 cites W2166227856 @default.
• W112830345 cites W2404033231 @default.
• W112830345 cites W2419163848 @default.
• W112830345 cites W2474917006 @default.
• W112830345 cites W42616220 @default.
• W112830345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8449675" @default.
• W112830345 hasPublicationYear "1993" @default.
• W112830345 type Work @default.
• W112830345 sameAs 112830345 @default.
• W112830345 citedByCount "0" @default.
• W112830345 crossrefType "journal-article" @default.
• W112830345 hasAuthorship W112830345A5059487056 @default.
• W112830345 hasAuthorship W112830345A5062234942 @default.
• W112830345 hasConcept C101660505 @default.
• W112830345 hasConcept C104317684 @default.
• W112830345 hasConcept C108625454 @default.
• W112830345 hasConcept C116084860 @default.
• W112830345 hasConcept C153074725 @default.
• W112830345 hasConcept C153911025 @default.
• W112830345 hasConcept C181199279 @default.
• W112830345 hasConcept C185592680 @default.
• W112830345 hasConcept C2778125326 @default.
• W112830345 hasConcept C2778173381 @default.
• W112830345 hasConcept C50476208 @default.
• W112830345 hasConcept C55493867 @default.
• W112830345 hasConcept C85265743 @default.
• W112830345 hasConcept C86803240 @default.
• W112830345 hasConceptScore W112830345C101660505 @default.
• W112830345 hasConceptScore W112830345C104317684 @default.
• W112830345 hasConceptScore W112830345C108625454 @default.
• W112830345 hasConceptScore W112830345C116084860 @default.
• W112830345 hasConceptScore W112830345C153074725 @default.
• W112830345 hasConceptScore W112830345C153911025 @default.
• W112830345 hasConceptScore W112830345C181199279 @default.
• W112830345 hasConceptScore W112830345C185592680 @default.
• W112830345 hasConceptScore W112830345C2778125326 @default.
• W112830345 hasConceptScore W112830345C2778173381 @default.
• W112830345 hasConceptScore W112830345C50476208 @default.
• W112830345 hasConceptScore W112830345C55493867 @default.
• W112830345 hasConceptScore W112830345C85265743 @default.
• W112830345 hasConceptScore W112830345C86803240 @default.
• W112830345 hasIssue "3" @default.
• W112830345 hasLocation W1128303451 @default.
• W112830345 hasOpenAccess W112830345 @default.
• W112830345 hasPrimaryLocation W1128303451 @default.
• W112830345 hasRelatedWork W112830345 @default.
• W112830345 hasRelatedWork W1439306656 @default.
• W112830345 hasRelatedWork W1507325186 @default.
• W112830345 hasRelatedWork W1965252847 @default.
• W112830345 hasRelatedWork W1982693670 @default.
• W112830345 hasRelatedWork W1988571907 @default.
• W112830345 hasRelatedWork W2012236280 @default.
• W112830345 hasRelatedWork W2047516844 @default.
• W112830345 hasRelatedWork W2093576243 @default.
• W112830345 hasRelatedWork W2149072815 @default.
• W112830345 hasVolume "34" @default.
• W112830345 isParatext "false" @default.
• W112830345 isRetracted "false" @default.
• W112830345 magId "112830345" @default.
• W112830345 workType "article" @default.