FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1128767881> ?p ?o ?g. }

• W1128767881 endingPage "823" @default.
• W1128767881 startingPage "817" @default.
• W1128767881 abstract "•It is unclear how data from clinical laboratories reflect the adult US population. •Biomarker data from >200,000 laboratory patient samples was compared with age- and sex-matched data from NHANES. •For most lipid and glycemic markers, the 2 cohorts differed by <5%. •Data collected in clinical laboratories are likely to be generalizable to the US population with few caveats. Background Clinical laboratory patient databases are an untapped source of valuable diagnostic and prognostic information. However, the lack of associated clinical and/or demographic information and questionable generalizability to nonpatient populations often limit utility of these data. Objectives This study compared levels of cardiometabolic biomarkers between a national clinical laboratory patient cohort (Health Diagnostic Laboratory [HD Lab]) and the US population as inferred from the National Health and Nutrition Examination Survey (NHANES, 2011–2012). Methods Sample sizes for HD Lab ranged from 199,000 to 739,000 and for NHANES from 2200 to 5300. The latter were weighted to represent the adult US population (∼220 million). Descriptive statistics were compared for body mass index, 5 lipid biomarkers, and 3 glycemic biomarkers. Results Using age- and sex-matched data, mean biomarker values (mg/dL unless noted) and percent differences (%) for HD Lab vs NHANES were body mass index (kg/m2), 29.1 vs 28.6 (1.7%); total cholesterol, 185 vs 193 (–4.1%); apolipoprotein B, 92 vs 90 (2.2%); low-density lipoprotein cholesterol, 107 vs 115 (–7%); high-density lipoprotein cholesterol, 53 vs 53 (0%); triglycerides, 128 vs 127 (0.8%); glucose, 99 vs 108 (–8.3%); insulin (uU/mL), 13.7 vs 13.4 (2.2%); and hemoglobin A1c (%), 5.6 vs 5.8 (–3.4%). Although all differences were statistically significant, only low-density lipoprotein cholesterol and glucose differed by more than 5%. These may reflect a greater use of medications among HD Lab patients and/or preanalytical factors. Conclusions Cardiometabolic risk markers from a national clinical laboratory were broadly similar to those of the US population; thus, with certain caveats, data from the former may be generalizable to the latter. Clinical laboratory patient databases are an untapped source of valuable diagnostic and prognostic information. However, the lack of associated clinical and/or demographic information and questionable generalizability to nonpatient populations often limit utility of these data. This study compared levels of cardiometabolic biomarkers between a national clinical laboratory patient cohort (Health Diagnostic Laboratory [HD Lab]) and the US population as inferred from the National Health and Nutrition Examination Survey (NHANES, 2011–2012). Sample sizes for HD Lab ranged from 199,000 to 739,000 and for NHANES from 2200 to 5300. The latter were weighted to represent the adult US population (∼220 million). Descriptive statistics were compared for body mass index, 5 lipid biomarkers, and 3 glycemic biomarkers. Using age- and sex-matched data, mean biomarker values (mg/dL unless noted) and percent differences (%) for HD Lab vs NHANES were body mass index (kg/m2), 29.1 vs 28.6 (1.7%); total cholesterol, 185 vs 193 (–4.1%); apolipoprotein B, 92 vs 90 (2.2%); low-density lipoprotein cholesterol, 107 vs 115 (–7%); high-density lipoprotein cholesterol, 53 vs 53 (0%); triglycerides, 128 vs 127 (0.8%); glucose, 99 vs 108 (–8.3%); insulin (uU/mL), 13.7 vs 13.4 (2.2%); and hemoglobin A1c (%), 5.6 vs 5.8 (–3.4%). Although all differences were statistically significant, only low-density lipoprotein cholesterol and glucose differed by more than 5%. These may reflect a greater use of medications among HD Lab patients and/or preanalytical factors. Cardiometabolic risk markers from a national clinical laboratory were broadly similar to those of the US population; thus, with certain caveats, data from the former may be generalizable to the latter." @default.
• W1128767881 created "2016-06-24" @default.
• W1128767881 creator A5003464950 @default.
• W1128767881 creator A5013947615 @default.
• W1128767881 creator A5019717682 @default.
• W1128767881 creator A5024824807 @default.
• W1128767881 creator A5026272891 @default.
• W1128767881 creator A5030132999 @default.
• W1128767881 creator A5036756435 @default.
• W1128767881 creator A5039606822 @default.
• W1128767881 creator A5055253078 @default.
• W1128767881 creator A5069614626 @default.
• W1128767881 creator A5083253617 @default.
• W1128767881 creator A5091093836 @default.
• W1128767881 date "2015-11-01" @default.
• W1128767881 modified "2023-09-25" @default.
• W1128767881 title "Comparison of cardiometabolic risk biomarkers from a national clinical laboratory with the US adult population" @default.
• W1128767881 cites W1722951830 @default.
• W1128767881 cites W1971441112 @default.
• W1128767881 cites W1985654122 @default.
• W1128767881 cites W1987968562 @default.
• W1128767881 cites W1991074140 @default.
• W1128767881 cites W2004074514 @default.
• W1128767881 cites W2023604660 @default.
• W1128767881 cites W2045054080 @default.
• W1128767881 cites W2062834072 @default.
• W1128767881 cites W2096466744 @default.
• W1128767881 cites W2107424758 @default.
• W1128767881 cites W2116404316 @default.
• W1128767881 cites W2122620643 @default.
• W1128767881 cites W2133983235 @default.
• W1128767881 cites W2153986659 @default.
• W1128767881 cites W2156317766 @default.
• W1128767881 cites W2158822657 @default.
• W1128767881 cites W2158901329 @default.
• W1128767881 cites W2315982688 @default.
• W1128767881 cites W2565800876 @default.
• W1128767881 cites W2887291237 @default.
• W1128767881 cites W4229768289 @default.
• W1128767881 cites W4241031718 @default.
• W1128767881 cites W4293084779 @default.
• W1128767881 cites W564948178 @default.
• W1128767881 doi "https://doi.org/10.1016/j.jacl.2015.07.014" @default.
• W1128767881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26687703" @default.
• W1128767881 hasPublicationYear "2015" @default.
• W1128767881 type Work @default.
• W1128767881 sameAs 1128767881 @default.
• W1128767881 citedByCount "9" @default.
• W1128767881 countsByYear W11287678812016 @default.
• W1128767881 countsByYear W11287678812019 @default.
• W1128767881 countsByYear W11287678812021 @default.
• W1128767881 countsByYear W11287678812022 @default.
• W1128767881 crossrefType "journal-article" @default.
• W1128767881 hasAuthorship W1128767881A5003464950 @default.
• W1128767881 hasAuthorship W1128767881A5013947615 @default.
• W1128767881 hasAuthorship W1128767881A5019717682 @default.
• W1128767881 hasAuthorship W1128767881A5024824807 @default.
• W1128767881 hasAuthorship W1128767881A5026272891 @default.
• W1128767881 hasAuthorship W1128767881A5030132999 @default.
• W1128767881 hasAuthorship W1128767881A5036756435 @default.
• W1128767881 hasAuthorship W1128767881A5039606822 @default.
• W1128767881 hasAuthorship W1128767881A5055253078 @default.
• W1128767881 hasAuthorship W1128767881A5069614626 @default.
• W1128767881 hasAuthorship W1128767881A5083253617 @default.
• W1128767881 hasAuthorship W1128767881A5091093836 @default.
• W1128767881 hasConcept C126322002 @default.
• W1128767881 hasConcept C185592680 @default.
• W1128767881 hasConcept C2779306644 @default.
• W1128767881 hasConcept C2779874844 @default.
• W1128767881 hasConcept C2780221984 @default.
• W1128767881 hasConcept C2780473172 @default.
• W1128767881 hasConcept C2781197716 @default.
• W1128767881 hasConcept C2908647359 @default.
• W1128767881 hasConcept C55493867 @default.
• W1128767881 hasConcept C71924100 @default.
• W1128767881 hasConcept C72563966 @default.
• W1128767881 hasConcept C99454951 @default.
• W1128767881 hasConceptScore W1128767881C126322002 @default.
• W1128767881 hasConceptScore W1128767881C185592680 @default.
• W1128767881 hasConceptScore W1128767881C2779306644 @default.
• W1128767881 hasConceptScore W1128767881C2779874844 @default.
• W1128767881 hasConceptScore W1128767881C2780221984 @default.
• W1128767881 hasConceptScore W1128767881C2780473172 @default.
• W1128767881 hasConceptScore W1128767881C2781197716 @default.
• W1128767881 hasConceptScore W1128767881C2908647359 @default.
• W1128767881 hasConceptScore W1128767881C55493867 @default.
• W1128767881 hasConceptScore W1128767881C71924100 @default.
• W1128767881 hasConceptScore W1128767881C72563966 @default.
• W1128767881 hasConceptScore W1128767881C99454951 @default.
• W1128767881 hasIssue "6" @default.
• W1128767881 hasLocation W11287678811 @default.
• W1128767881 hasLocation W11287678812 @default.
• W1128767881 hasOpenAccess W1128767881 @default.
• W1128767881 hasPrimaryLocation W11287678811 @default.
• W1128767881 hasRelatedWork W2015670292 @default.
• W1128767881 hasRelatedWork W2065964325 @default.
• W1128767881 hasRelatedWork W2110217064 @default.
• W1128767881 hasRelatedWork W2517440302 @default.

• next