Matches in SemOpenAlex for { <https://semopenalex.org/work/W1128908913> ?p ?o ?g. }
- W1128908913 endingPage "383" @default.
- W1128908913 startingPage "376" @default.
- W1128908913 abstract "Tissue development/remodeling requires modulations in both cellular architecture and phenotype. Aberration in these processes leads to tumorigenesis. During the pregnancy/lactation cycle the mammary epithelial cells undergo complex morphological and phenotypic programs resulting in the acquisition of apical/basal (A/B) polarization and cellular maturation necessary for proper lactation. Still the hormonal regulations and cellular mechanisms controlling these events are not entirely elucidated. Here we show that prolactin (PRL)/Jak2 pathway in mammary epithelial cells uniquely signals to establish A/B polarity as determined by the apical localization of the tight junction protein zona occludens 1 (ZO-1) and the basal/lateral localization of E-cadherin, and the apical trafficking of lipid droplets. As well, our results indicate that this pathway regulates mammary stem cell hierarchy by inducing the differentiation of luminal progenitor (EpCAMhi/CD49fhi) cells to mature luminal (EpCAMhi/CD49flow) cells. Moreover, our data indicate that PRL/Jak2 coordinates both of these cellular events through limiting the mitogen activated protein kinase (Erk1/2) pathway. Together our findings define a novel unifying mechanism coupling mammary epithelial cell A/B polarization and terminal differentiation." @default.
- W1128908913 created "2016-06-24" @default.
- W1128908913 creator A5005448485 @default.
- W1128908913 creator A5018942659 @default.
- W1128908913 creator A5025132882 @default.
- W1128908913 creator A5042929692 @default.
- W1128908913 creator A5062979677 @default.
- W1128908913 creator A5091794314 @default.
- W1128908913 date "2015-09-01" @default.
- W1128908913 modified "2023-10-14" @default.
- W1128908913 title "Prolactin/Jak2 directs apical/basal polarization and luminal linage maturation of mammary epithelial cells through regulation of the Erk1/2 pathway" @default.
- W1128908913 cites W132416300 @default.
- W1128908913 cites W1520963173 @default.
- W1128908913 cites W1563762782 @default.
- W1128908913 cites W1845680073 @default.
- W1128908913 cites W1969890794 @default.
- W1128908913 cites W1970908631 @default.
- W1128908913 cites W1973642840 @default.
- W1128908913 cites W1977341142 @default.
- W1128908913 cites W1988134165 @default.
- W1128908913 cites W1994683536 @default.
- W1128908913 cites W1998301679 @default.
- W1128908913 cites W1999591980 @default.
- W1128908913 cites W2011761081 @default.
- W1128908913 cites W2018896819 @default.
- W1128908913 cites W2019323840 @default.
- W1128908913 cites W2028919524 @default.
- W1128908913 cites W2031179661 @default.
- W1128908913 cites W2032196335 @default.
- W1128908913 cites W2034072513 @default.
- W1128908913 cites W2065107932 @default.
- W1128908913 cites W2069354876 @default.
- W1128908913 cites W2093010275 @default.
- W1128908913 cites W2101141712 @default.
- W1128908913 cites W2102209707 @default.
- W1128908913 cites W2114964628 @default.
- W1128908913 cites W2133196685 @default.
- W1128908913 cites W2134579258 @default.
- W1128908913 cites W2135571525 @default.
- W1128908913 cites W2137204308 @default.
- W1128908913 cites W2143584784 @default.
- W1128908913 cites W2144839053 @default.
- W1128908913 cites W2147028876 @default.
- W1128908913 cites W2148227665 @default.
- W1128908913 cites W2161930851 @default.
- W1128908913 cites W2419265161 @default.
- W1128908913 cites W48270215 @default.
- W1128908913 doi "https://doi.org/10.1016/j.scr.2015.08.001" @default.
- W1128908913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26318719" @default.
- W1128908913 hasPublicationYear "2015" @default.
- W1128908913 type Work @default.
- W1128908913 sameAs 1128908913 @default.
- W1128908913 citedByCount "23" @default.
- W1128908913 countsByYear W11289089132016 @default.
- W1128908913 countsByYear W11289089132017 @default.
- W1128908913 countsByYear W11289089132018 @default.
- W1128908913 countsByYear W11289089132019 @default.
- W1128908913 countsByYear W11289089132020 @default.
- W1128908913 countsByYear W11289089132021 @default.
- W1128908913 countsByYear W11289089132022 @default.
- W1128908913 crossrefType "journal-article" @default.
- W1128908913 hasAuthorship W1128908913A5005448485 @default.
- W1128908913 hasAuthorship W1128908913A5018942659 @default.
- W1128908913 hasAuthorship W1128908913A5025132882 @default.
- W1128908913 hasAuthorship W1128908913A5042929692 @default.
- W1128908913 hasAuthorship W1128908913A5062979677 @default.
- W1128908913 hasAuthorship W1128908913A5091794314 @default.
- W1128908913 hasBestOaLocation W11289089131 @default.
- W1128908913 hasConcept C104317684 @default.
- W1128908913 hasConcept C121608353 @default.
- W1128908913 hasConcept C126322002 @default.
- W1128908913 hasConcept C134018914 @default.
- W1128908913 hasConcept C148738053 @default.
- W1128908913 hasConcept C1491633281 @default.
- W1128908913 hasConcept C184235292 @default.
- W1128908913 hasConcept C201750760 @default.
- W1128908913 hasConcept C2778001805 @default.
- W1128908913 hasConcept C2779064019 @default.
- W1128908913 hasConcept C28328180 @default.
- W1128908913 hasConcept C49353375 @default.
- W1128908913 hasConcept C529295009 @default.
- W1128908913 hasConcept C530470458 @default.
- W1128908913 hasConcept C54355233 @default.
- W1128908913 hasConcept C55493867 @default.
- W1128908913 hasConcept C62478195 @default.
- W1128908913 hasConcept C71315377 @default.
- W1128908913 hasConcept C71924100 @default.
- W1128908913 hasConcept C86803240 @default.
- W1128908913 hasConcept C95444343 @default.
- W1128908913 hasConcept C97029542 @default.
- W1128908913 hasConceptScore W1128908913C104317684 @default.
- W1128908913 hasConceptScore W1128908913C121608353 @default.
- W1128908913 hasConceptScore W1128908913C126322002 @default.
- W1128908913 hasConceptScore W1128908913C134018914 @default.
- W1128908913 hasConceptScore W1128908913C148738053 @default.
- W1128908913 hasConceptScore W1128908913C1491633281 @default.
- W1128908913 hasConceptScore W1128908913C184235292 @default.
- W1128908913 hasConceptScore W1128908913C201750760 @default.