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• W1129407908 abstract "Peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α) is a transcriptional coactivator involved in mitochondrial biogenesis, oxidative stress response, and energy metabolism. PGC-1α is part of an energy sensing network that translates environmental influences into alterations in gene expression of mainly mitochondrial molecular pathways. A role in neuroprotection has been implicated for PGC-1α in the context of mitochondrial expression networks. Our research group has previously established a transgenic mouse line with stable overexpression of PGC-1α in brain neurons. Transgenic overexpression of PGC-1α is associated with an enhanced functional state of mitochondrial energy production. In the context of neurodegenerative processes, brain neurons of PGC-1α transgenic mice are protected against oxidative stressors in the MPTP mouse model of Parkinson’s Disease. To further characterize the transcriptional activity of PGC-1α regulated gene networks in brains of transgenic mice, a quantitative real-time PCR based system was established. Gene expression was measured for a subset of genes found to be differentially regulated in a microarray based screening of RNA obtained from hippocampus and cortex of PGC-1α transgenic mice. Increased PGC-1α gene expression was found in hippocampus and cortex of PGC-1α transgenic mice, and their translation into protein was confirmed immunohistochemically. Expression analysis revealed significant changes in mRNA levels of PGC-1α controlled molecular pathways involved in mitochondrial energy production and antioxidant responses. Furthermore, alterations in the expression of some non-mitochondrial genes with established links to neurodegeneration were observed. Furthermore, a change in GABAA receptor subunit expression was detected. In accordance with previous studies on the PGC-1α transgenic mouse line, these findings suggest that differential gene expression associated with PGC-1α overexpression contributes to an enhanced functional state of neurons in hippocampus and cortex of PGC-1α transgenic mice. Increased knowledge about the transcriptional modulation of neuronal genes regulated by PGC-1α can lead to better insights into mechanisms governing neurodegeneration and neuroprotective pathways. Pharmacological modulation of PGC-1α activity may be a feasible approach for neuroprotective treatments in neurodegenerative diseases, such as Parkinson’s Disease." @default.
• W1129407908 created "2016-06-24" @default.
• W1129407908 creator A5002217554 @default.
• W1129407908 date "2013-01-01" @default.
• W1129407908 modified "2023-09-24" @default.
• W1129407908 title "Analysis of neuronal transcripts of PGC-1α transgenic mice" @default.
• W1129407908 cites W1504584187 @default.
• W1129407908 cites W1518185094 @default.
• W1129407908 cites W1547758273 @default.
• W1129407908 cites W1780139514 @default.
• W1129407908 cites W1964876127 @default.
• W1129407908 cites W1966985989 @default.
• W1129407908 cites W1968576007 @default.
• W1129407908 cites W1970944551 @default.
• W1129407908 cites W1971082641 @default.
• W1129407908 cites W1977252372 @default.
• W1129407908 cites W1978119802 @default.
• W1129407908 cites W1981877284 @default.
• W1129407908 cites W1982029249 @default.
• W1129407908 cites W1982686540 @default.
• W1129407908 cites W1984156662 @default.
• W1129407908 cites W1986068161 @default.
• W1129407908 cites W1986193590 @default.
• W1129407908 cites W1986216002 @default.
• W1129407908 cites W1991691390 @default.
• W1129407908 cites W1992371392 @default.
• W1129407908 cites W1995354490 @default.
• W1129407908 cites W1995804263 @default.
• W1129407908 cites W1997312454 @default.
• W1129407908 cites W2004514374 @default.
• W1129407908 cites W2008632158 @default.
• W1129407908 cites W2016521227 @default.
• W1129407908 cites W2016693012 @default.
• W1129407908 cites W2017741706 @default.
• W1129407908 cites W2018427433 @default.
• W1129407908 cites W2024943443 @default.
• W1129407908 cites W2025937429 @default.
• W1129407908 cites W2033620247 @default.
• W1129407908 cites W2034641256 @default.
• W1129407908 cites W2037075564 @default.
• W1129407908 cites W2044782567 @default.
• W1129407908 cites W2044883494 @default.
• W1129407908 cites W2047551220 @default.
• W1129407908 cites W2047701363 @default.
• W1129407908 cites W2048897966 @default.
• W1129407908 cites W2050897300 @default.
• W1129407908 cites W2052381603 @default.
• W1129407908 cites W2053506736 @default.
• W1129407908 cites W2054415450 @default.
• W1129407908 cites W2054663416 @default.
• W1129407908 cites W2057879006 @default.
• W1129407908 cites W2063343639 @default.
• W1129407908 cites W2065408367 @default.
• W1129407908 cites W2070895853 @default.
• W1129407908 cites W2071955212 @default.
• W1129407908 cites W2075895907 @default.
• W1129407908 cites W2077529180 @default.
• W1129407908 cites W2080995987 @default.
• W1129407908 cites W2081854210 @default.
• W1129407908 cites W2082298489 @default.
• W1129407908 cites W2082629592 @default.
• W1129407908 cites W2084127055 @default.
• W1129407908 cites W2087393295 @default.
• W1129407908 cites W2089606595 @default.
• W1129407908 cites W2089915293 @default.
• W1129407908 cites W2090946270 @default.
• W1129407908 cites W2091673304 @default.
• W1129407908 cites W2091896743 @default.
• W1129407908 cites W2101600160 @default.
• W1129407908 cites W2105404724 @default.
• W1129407908 cites W2107277218 @default.
• W1129407908 cites W2107324877 @default.
• W1129407908 cites W2108244474 @default.
• W1129407908 cites W2109840309 @default.
• W1129407908 cites W2111116481 @default.
• W1129407908 cites W2111376434 @default.
• W1129407908 cites W2111501638 @default.
• W1129407908 cites W2111682630 @default.
• W1129407908 cites W2113515610 @default.
• W1129407908 cites W2114570899 @default.
• W1129407908 cites W2121966499 @default.
• W1129407908 cites W2124105006 @default.
• W1129407908 cites W2130497877 @default.
• W1129407908 cites W2131007152 @default.
• W1129407908 cites W2131415852 @default.
• W1129407908 cites W2131492087 @default.
• W1129407908 cites W2133444149 @default.
• W1129407908 cites W2139233019 @default.
• W1129407908 cites W2143364665 @default.
• W1129407908 cites W2144361706 @default.
• W1129407908 cites W2144600435 @default.
• W1129407908 cites W2145954079 @default.
• W1129407908 cites W2147335276 @default.
• W1129407908 cites W2148386814 @default.
• W1129407908 cites W2150349809 @default.
• W1129407908 cites W2152165298 @default.
• W1129407908 cites W2154761807 @default.
• W1129407908 cites W2155446034 @default.
• W1129407908 cites W2163863334 @default.
• W1129407908 cites W2168208715 @default.

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