Matches in SemOpenAlex for { <https://semopenalex.org/work/W1129657888> ?p ?o ?g. }
- W1129657888 endingPage "1339" @default.
- W1129657888 startingPage "1334" @default.
- W1129657888 abstract "The aim of this study is to explore how quercetin interacts with pancreatic cancer stem-like cells and the mechanism underlying the effective quercetin-mediated suppression.A model of pancreatic cancer stem-like cells was generated by using a sphere formation culture system. A comparative analysis was performed between the parent cells and pancreatic cancer stem-like cells with a related treatment strategy focusing on cancer stem cell (CSC) properties and drug-resistance-related mechanisms in vitro.Our data show that pancreatic cancer stem-like cells have greater resistance to gemcitabine and stronger CSC properties compared with the parent cells. In contrast to the pancreatic cancer stem-like cells, overexpression of β-catenin was observed in the parent cells. Quercetin suppressed proliferation, invasion and self-renewal capacity, and CSC surface markers expression, with alterations of β-catenin in pancreatic cancer stem-like cells. The combination of quercetin and gemcitabine can reduce tumor growth and decrease drug resistance in pancreatic cancer.β-Catenin plays an important role in maintenance and progression of pancreatic cancer. Targeting β-catenin using quercetin combined with gemcitabine may be a treatment strategy to improve prognosis in patients with pancreatic cancer." @default.
- W1129657888 created "2016-06-24" @default.
- W1129657888 creator A5022038376 @default.
- W1129657888 creator A5031768294 @default.
- W1129657888 creator A5041426946 @default.
- W1129657888 creator A5058165407 @default.
- W1129657888 creator A5061744251 @default.
- W1129657888 creator A5066170115 @default.
- W1129657888 date "2015-11-01" @default.
- W1129657888 modified "2023-10-16" @default.
- W1129657888 title "Quercetin Mediates β-Catenin in Pancreatic Cancer Stem-Like Cells" @default.
- W1129657888 cites W1580488470 @default.
- W1129657888 cites W1982694707 @default.
- W1129657888 cites W1984560157 @default.
- W1129657888 cites W1987708512 @default.
- W1129657888 cites W1987868206 @default.
- W1129657888 cites W1998196049 @default.
- W1129657888 cites W2014980225 @default.
- W1129657888 cites W2017990196 @default.
- W1129657888 cites W2034189137 @default.
- W1129657888 cites W2034893372 @default.
- W1129657888 cites W2049368749 @default.
- W1129657888 cites W2062069198 @default.
- W1129657888 cites W2063188304 @default.
- W1129657888 cites W2063703361 @default.
- W1129657888 cites W2068007920 @default.
- W1129657888 cites W2081053626 @default.
- W1129657888 cites W2097755642 @default.
- W1129657888 cites W2105869334 @default.
- W1129657888 cites W2106787323 @default.
- W1129657888 cites W2117277249 @default.
- W1129657888 cites W2117491278 @default.
- W1129657888 cites W2119451122 @default.
- W1129657888 cites W2132370499 @default.
- W1129657888 cites W2134987819 @default.
- W1129657888 cites W2151253787 @default.
- W1129657888 cites W2158812368 @default.
- W1129657888 cites W2161884651 @default.
- W1129657888 cites W2163968551 @default.
- W1129657888 cites W2166082118 @default.
- W1129657888 cites W4253186968 @default.
- W1129657888 doi "https://doi.org/10.1097/mpa.0000000000000400" @default.
- W1129657888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26284537" @default.
- W1129657888 hasPublicationYear "2015" @default.
- W1129657888 type Work @default.
- W1129657888 sameAs 1129657888 @default.
- W1129657888 citedByCount "28" @default.
- W1129657888 countsByYear W11296578882016 @default.
- W1129657888 countsByYear W11296578882017 @default.
- W1129657888 countsByYear W11296578882018 @default.
- W1129657888 countsByYear W11296578882019 @default.
- W1129657888 countsByYear W11296578882020 @default.
- W1129657888 countsByYear W11296578882021 @default.
- W1129657888 countsByYear W11296578882022 @default.
- W1129657888 countsByYear W11296578882023 @default.
- W1129657888 crossrefType "journal-article" @default.
- W1129657888 hasAuthorship W1129657888A5022038376 @default.
- W1129657888 hasAuthorship W1129657888A5031768294 @default.
- W1129657888 hasAuthorship W1129657888A5041426946 @default.
- W1129657888 hasAuthorship W1129657888A5058165407 @default.
- W1129657888 hasAuthorship W1129657888A5061744251 @default.
- W1129657888 hasAuthorship W1129657888A5066170115 @default.
- W1129657888 hasConcept C121608353 @default.
- W1129657888 hasConcept C126322002 @default.
- W1129657888 hasConcept C2780210213 @default.
- W1129657888 hasConcept C2780258809 @default.
- W1129657888 hasConcept C28328180 @default.
- W1129657888 hasConcept C502942594 @default.
- W1129657888 hasConcept C55427017 @default.
- W1129657888 hasConcept C71924100 @default.
- W1129657888 hasConcept C86803240 @default.
- W1129657888 hasConcept C95444343 @default.
- W1129657888 hasConcept C96232424 @default.
- W1129657888 hasConceptScore W1129657888C121608353 @default.
- W1129657888 hasConceptScore W1129657888C126322002 @default.
- W1129657888 hasConceptScore W1129657888C2780210213 @default.
- W1129657888 hasConceptScore W1129657888C2780258809 @default.
- W1129657888 hasConceptScore W1129657888C28328180 @default.
- W1129657888 hasConceptScore W1129657888C502942594 @default.
- W1129657888 hasConceptScore W1129657888C55427017 @default.
- W1129657888 hasConceptScore W1129657888C71924100 @default.
- W1129657888 hasConceptScore W1129657888C86803240 @default.
- W1129657888 hasConceptScore W1129657888C95444343 @default.
- W1129657888 hasConceptScore W1129657888C96232424 @default.
- W1129657888 hasIssue "8" @default.
- W1129657888 hasLocation W11296578881 @default.
- W1129657888 hasLocation W11296578882 @default.
- W1129657888 hasOpenAccess W1129657888 @default.
- W1129657888 hasPrimaryLocation W11296578881 @default.
- W1129657888 hasRelatedWork W1995076802 @default.
- W1129657888 hasRelatedWork W2043890160 @default.
- W1129657888 hasRelatedWork W2089179463 @default.
- W1129657888 hasRelatedWork W2101890232 @default.
- W1129657888 hasRelatedWork W2148244006 @default.
- W1129657888 hasRelatedWork W2319496893 @default.
- W1129657888 hasRelatedWork W2740937526 @default.
- W1129657888 hasRelatedWork W2917514204 @default.
- W1129657888 hasRelatedWork W4311308018 @default.