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• W113004893 endingPage "45.4" @default.
• W113004893 startingPage "45.4" @default.
• W113004893 abstract "Abstract RICK, a serine-threonine kinase, functions downstream of the pattern-recognition receptors Nod1 and Nod2 to mediate NF-kB and MAPK activation in response to specific microbial stimuli. However, the function of RICK in the recognition and host defense of Gram-negative bacteria remains poorly understood. We report here that infection of wild-type and RICK-deficient macrophages with Pseudomonas aeruginosa and Escherichia coli, elicited comparable activation of NF-kB and MAPKs as well as secretion of pro-inflammatory cytokines. However, production of IL-6 and IL-1b induced by these Gram-negative bacteria was impaired in RICK-deficient macrophages when the cells were previously stimulated with LPS or E. coli. The diminished pro-inflammatory response of RICK-deficient macrophages to bacteria was associated with reduced activation of NF-kB and MAPKs. Importantly, mutant mice deficient in RICK were less susceptible than wild-type mice to P. aeruginosa infection when the animals were previously stimulated with LPS. The reduced lethality of RICK-deficient mice infected with P. aeruginosa was independent of pathogen clearance, but was associated with diminished production of pro-inflammatory molecules in vivo. These results demonstrate that RICK contributes to the induction of pro-inflammatory responses and susceptibility to Gram-negative bacteria after exposure to LPS, a condition that is associated with reduced TLR signaling." @default.
• W113004893 created "2016-06-24" @default.
• W113004893 creator A5040117830 @default.
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• W113004893 date "2009-04-01" @default.
• W113004893 modified "2023-10-17" @default.
• W113004893 title "RICK/RIP2 Promotes Inflammation and Lethality after Gram-Negative Bacterial Infection in Mice Stimulated with Lipopolysaccharide (45.4)" @default.
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• W113004893 doi "https://doi.org/10.4049/jimmunol.182.supp.45.4" @default.
• W113004893 hasPublicationYear "2009" @default.
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