FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W113011105> ?p ?o ?g. }

• W113011105 endingPage "5729" @default.
• W113011105 startingPage "5722" @default.
• W113011105 abstract "The possible role of Met-tRNAf deacylase in the regulation of protein synthesis in rabbit reticulocyte lysate by the hemin-controlled translational repressor (HCR) or the double-stranded RNA-activated inhibitor (dsI) has been examined. Inhibition of protein synthesis by either HCR or dsI is associated with a marked increase in the steady state level of 48 S initiation complexes, containing a 40 S ribosomal subunit, globin mRNA, and a reduced level of Met-tRNAf, suggesting that the rate of 60 S subunit addition may be inhibited and that subunit-bound Met-tRNAf may become deacylated by Met-tRNAf deacylase. The addition of highly purified Met-tRNAf deacylase to lysate samples incubated with HCR or dsI reduces the [35S]Met-tRNAf labeling of 48 S complexes to even a lower level but has no effect on the high level of [35S]Met-tRNAf associated with 43 S complexes in the plus hemin control. The effect of added deacylase on the labeling of 48 S complexes with [35S]Met-tRNAf can be overcome by adding eIF-5 or a soluble reticulocyte protein that has been termed the reversing factor, but not by the addition of eIF-2. Added deacylase has no effect on the level of mRNA in 48 S complexes or the labeling of these complexes with [35S]fMet-tRNAf. When lysate samples were labeled with Met-tRNAf, purified from wheat germ or yeast, and doubly labeled with 32P at the 5' end and [35S]methionine aminoacylation, HCR reduced the level of 32P and 35S-labeled tRNAMetf in 48 S complexes to a similar degree, suggesting that once it has become deacylated, tRNAMetf dissociates from the 40 S subunit." @default.
• W113011105 created "2016-06-24" @default.
• W113011105 creator A5021721465 @default.
• W113011105 creator A5053579827 @default.
• W113011105 creator A5066154498 @default.
• W113011105 date "1982-05-01" @default.
• W113011105 modified "2023-10-18" @default.
• W113011105 title "Effect of Met-tRNAf deacylase on polypeptide chain initiation in rabbit reticulocyte lysate." @default.
• W113011105 cites W1506370454 @default.
• W113011105 cites W1506911907 @default.
• W113011105 cites W1531584941 @default.
• W113011105 cites W1543884867 @default.
• W113011105 cites W1552257329 @default.
• W113011105 cites W1574158932 @default.
• W113011105 cites W1581060680 @default.
• W113011105 cites W17120247 @default.
• W113011105 cites W1965116617 @default.
• W113011105 cites W1965751321 @default.
• W113011105 cites W1966461376 @default.
• W113011105 cites W1968719690 @default.
• W113011105 cites W1968817562 @default.
• W113011105 cites W1970039374 @default.
• W113011105 cites W1972438528 @default.
• W113011105 cites W1987695047 @default.
• W113011105 cites W1989683219 @default.
• W113011105 cites W1996411182 @default.
• W113011105 cites W2003782814 @default.
• W113011105 cites W2008698899 @default.
• W113011105 cites W2016407154 @default.
• W113011105 cites W2019715256 @default.
• W113011105 cites W2025888779 @default.
• W113011105 cites W2038051327 @default.
• W113011105 cites W2040393821 @default.
• W113011105 cites W2042668209 @default.
• W113011105 cites W2047736078 @default.
• W113011105 cites W2050428821 @default.
• W113011105 cites W2054044362 @default.
• W113011105 cites W2057272748 @default.
• W113011105 cites W2057635096 @default.
• W113011105 cites W2062417484 @default.
• W113011105 cites W2069688277 @default.
• W113011105 cites W2074148999 @default.
• W113011105 cites W2085627848 @default.
• W113011105 cites W2086540277 @default.
• W113011105 cites W2088987839 @default.
• W113011105 cites W2091315522 @default.
• W113011105 cites W2095461661 @default.
• W113011105 cites W2116221306 @default.
• W113011105 cites W2148881556 @default.
• W113011105 cites W2396626131 @default.
• W113011105 cites W58563855 @default.
• W113011105 cites W613881627 @default.
• W113011105 doi "https://doi.org/10.1016/s0021-9258(19)83838-3" @default.
• W113011105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6917849" @default.
• W113011105 hasPublicationYear "1982" @default.
• W113011105 type Work @default.
• W113011105 sameAs 113011105 @default.
• W113011105 citedByCount "12" @default.
• W113011105 crossrefType "journal-article" @default.
• W113011105 hasAuthorship W113011105A5021721465 @default.
• W113011105 hasAuthorship W113011105A5053579827 @default.
• W113011105 hasAuthorship W113011105A5066154498 @default.
• W113011105 hasBestOaLocation W1130111051 @default.
• W113011105 hasConcept C104317684 @default.
• W113011105 hasConcept C105580179 @default.
• W113011105 hasConcept C153911025 @default.
• W113011105 hasConcept C185592680 @default.
• W113011105 hasConcept C2778403015 @default.
• W113011105 hasConcept C2779884254 @default.
• W113011105 hasConcept C38652104 @default.
• W113011105 hasConcept C41008148 @default.
• W113011105 hasConcept C55493867 @default.
• W113011105 hasConcept C57409179 @default.
• W113011105 hasConcept C86803240 @default.
• W113011105 hasConcept C98274493 @default.
• W113011105 hasConceptScore W113011105C104317684 @default.
• W113011105 hasConceptScore W113011105C105580179 @default.
• W113011105 hasConceptScore W113011105C153911025 @default.
• W113011105 hasConceptScore W113011105C185592680 @default.
• W113011105 hasConceptScore W113011105C2778403015 @default.
• W113011105 hasConceptScore W113011105C2779884254 @default.
• W113011105 hasConceptScore W113011105C38652104 @default.
• W113011105 hasConceptScore W113011105C41008148 @default.
• W113011105 hasConceptScore W113011105C55493867 @default.
• W113011105 hasConceptScore W113011105C57409179 @default.
• W113011105 hasConceptScore W113011105C86803240 @default.
• W113011105 hasConceptScore W113011105C98274493 @default.
• W113011105 hasIssue "10" @default.
• W113011105 hasLocation W1130111051 @default.
• W113011105 hasOpenAccess W113011105 @default.
• W113011105 hasPrimaryLocation W1130111051 @default.
• W113011105 hasRelatedWork W1518640128 @default.
• W113011105 hasRelatedWork W1532810559 @default.
• W113011105 hasRelatedWork W1603381860 @default.
• W113011105 hasRelatedWork W1969508607 @default.
• W113011105 hasRelatedWork W2038941736 @default.
• W113011105 hasRelatedWork W2046489735 @default.
• W113011105 hasRelatedWork W2483654845 @default.

• next