Matches in SemOpenAlex for { <https://semopenalex.org/work/W1130475897> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1130475897 abstract "A recent trend in bioanalysis is the introduction of molecularly imprinted solid-phase extraction (MISPE) due to their tailor-made selectivity for the determination of traces of analytes in complex matrices by liquid chromatography (LC) [1]. In order to selectively extract methotrexate (MTX), a powerful anti-cancer agent, from plasma samples, molecularly imprinted polymers (MIPs) were prepared against MTX by using two structural analogues, trimethoprim and N-Z-L-glutamic acid, as templates [2-3]. Non-imprinted polymers (NIPs) were also synthesized without template. These sorbents, packed in disposable extraction cartridges (DECs), were then evaluated for at-line solid phase extraction (SPE) by means of a sample processor (ASPEC system) and coupled directly to LC. The separation was performed on octadecyl silica stationary phase with a mixture of 10 mM phosphate buffer (pH 2.5) and methanol (77:23; v/v) as mobile phase. MTX was monitored photometrically at 307 nm. The SPE conditions were studied by means of experimental design in order to investigate the retention selectivity and try to explain the retention mechanisms of MTX on the MIPs. The MISPE selectivity was exploited in the washing step to transform non-selective interactions into selective interactions." @default.
- W1130475897 created "2016-06-24" @default.
- W1130475897 creator A5014292749 @default.
- W1130475897 creator A5036773147 @default.
- W1130475897 creator A5038063185 @default.
- W1130475897 creator A5042064422 @default.
- W1130475897 creator A5070531018 @default.
- W1130475897 creator A5073501858 @default.
- W1130475897 creator A5078249208 @default.
- W1130475897 creator A5083606998 @default.
- W1130475897 date "2005-09-01" @default.
- W1130475897 modified "2023-09-25" @default.
- W1130475897 title "OPTIMIZATION OF MOLECULARLY IMPRINTED SOLID-PHASE EXTRACTION BY MEANS OF EXPERIMENTAL DESIGN PRIOR TO THE DETERMINATION OF METHOTREXATE IN HUMAN PLASMA" @default.
- W1130475897 hasPublicationYear "2005" @default.
- W1130475897 type Work @default.
- W1130475897 sameAs 1130475897 @default.
- W1130475897 citedByCount "0" @default.
- W1130475897 crossrefType "journal-article" @default.
- W1130475897 hasAuthorship W1130475897A5014292749 @default.
- W1130475897 hasAuthorship W1130475897A5036773147 @default.
- W1130475897 hasAuthorship W1130475897A5038063185 @default.
- W1130475897 hasAuthorship W1130475897A5042064422 @default.
- W1130475897 hasAuthorship W1130475897A5070531018 @default.
- W1130475897 hasAuthorship W1130475897A5073501858 @default.
- W1130475897 hasAuthorship W1130475897A5078249208 @default.
- W1130475897 hasAuthorship W1130475897A5083606998 @default.
- W1130475897 hasConcept C10390740 @default.
- W1130475897 hasConcept C118792377 @default.
- W1130475897 hasConcept C137535248 @default.
- W1130475897 hasConcept C161790260 @default.
- W1130475897 hasConcept C162602672 @default.
- W1130475897 hasConcept C178790620 @default.
- W1130475897 hasConcept C179998833 @default.
- W1130475897 hasConcept C185592680 @default.
- W1130475897 hasConcept C2778576202 @default.
- W1130475897 hasConcept C39442485 @default.
- W1130475897 hasConcept C43617362 @default.
- W1130475897 hasConcept C4725764 @default.
- W1130475897 hasConcept C81426234 @default.
- W1130475897 hasConceptScore W1130475897C10390740 @default.
- W1130475897 hasConceptScore W1130475897C118792377 @default.
- W1130475897 hasConceptScore W1130475897C137535248 @default.
- W1130475897 hasConceptScore W1130475897C161790260 @default.
- W1130475897 hasConceptScore W1130475897C162602672 @default.
- W1130475897 hasConceptScore W1130475897C178790620 @default.
- W1130475897 hasConceptScore W1130475897C179998833 @default.
- W1130475897 hasConceptScore W1130475897C185592680 @default.
- W1130475897 hasConceptScore W1130475897C2778576202 @default.
- W1130475897 hasConceptScore W1130475897C39442485 @default.
- W1130475897 hasConceptScore W1130475897C43617362 @default.
- W1130475897 hasConceptScore W1130475897C4725764 @default.
- W1130475897 hasConceptScore W1130475897C81426234 @default.
- W1130475897 hasLocation W11304758971 @default.
- W1130475897 hasOpenAccess W1130475897 @default.
- W1130475897 hasPrimaryLocation W11304758971 @default.
- W1130475897 hasRelatedWork W1776893490 @default.
- W1130475897 hasRelatedWork W2003229634 @default.
- W1130475897 hasRelatedWork W2003909379 @default.
- W1130475897 hasRelatedWork W2010368084 @default.
- W1130475897 hasRelatedWork W2040404438 @default.
- W1130475897 hasRelatedWork W2043496809 @default.
- W1130475897 hasRelatedWork W2083958401 @default.
- W1130475897 hasRelatedWork W2513855931 @default.
- W1130475897 hasRelatedWork W2555088631 @default.
- W1130475897 hasRelatedWork W2565010107 @default.
- W1130475897 hasRelatedWork W2750955741 @default.
- W1130475897 hasRelatedWork W2793277722 @default.
- W1130475897 hasRelatedWork W2810536626 @default.
- W1130475897 hasRelatedWork W2905824878 @default.
- W1130475897 hasRelatedWork W2909161007 @default.
- W1130475897 hasRelatedWork W3084430484 @default.
- W1130475897 hasRelatedWork W3110788974 @default.
- W1130475897 hasRelatedWork W3194076859 @default.
- W1130475897 hasRelatedWork W3197677398 @default.
- W1130475897 hasRelatedWork W337044406 @default.
- W1130475897 isParatext "false" @default.
- W1130475897 isRetracted "false" @default.
- W1130475897 magId "1130475897" @default.
- W1130475897 workType "article" @default.