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- W1130977540 abstract "1852 Objectives Investigate the role of whole body scan (WBS) in addition to cardiac FDG PET/CT during the evaluation of patients for active cardiac sarcoidosis (ACS). Methods Retrospective analysis of 60 individuals undergoing WBS and cardiac FDG PET/CT during the same imaging session for evaluation for ACS. Patients were instructed to have a low carbohydrate high-lipid diet for 24 hrs and fast 12 hours prior to imaging in order to minimize myocardial glucose utilization. On the study date individuals first underwent a resting myocardial perfusion study with Rb-82 or N-13 ammonia. Then a FDG dedicated cardiac scan (Field of view 15 cm) was performed followed by WBS (base of the skull to mid-thighs) PET/CT. ACS was defined as focally increased FDG uptake in the left ventricle except for the lateral wall. Extra cardiac sarcoid involvement was considered likely if SUV max in a given lesion was greater than SUV average in the liver. Results A total of 21 subjects had evidence of ACS, 34 were considered as no-ACS, and 5 had equivocal results and were not included in subsequent analysis. Age (47±10 vs. 50±12 yrs, P 0.4), LV ejection fraction (44±14 vs. 44±15%, P =0.97), history of biopsy-proven systemic sarcoidosis (94 vs. 89%, P=0.6) and immunosuppressant therapy at the time of study (52 vs. 53%, P=0.97) were not significantly different between individuals with and without ACS. However, presence of abnormal extra-cardiac FDG activity in the WBS was significantly higher in the ACS (n=19, 90.5%) than non-ACS (n=22, 65%, P 0.03). In fact, only 2 subjects showed absence of abnormal extracardiac FDG activity in the ACS group. Importantly, in a sub analysis of patients off immunosuppressant therapy at the time of study (n=26), all ACS patients (n=10) showed abnormal extracardiac FDG uptake in WBS vs. 50 % (n=8) in the non-ACS group (p=0.007). Conclusions Abnormal extracardiac FDG activity in WBS suggestive of active systemic sarcoidosis may support the diagnosis of active myocardial involvement especially in the absence of concomitant immunosuppressant therapy" @default.
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- W1130977540 date "2012-05-01" @default.
- W1130977540 modified "2023-09-25" @default.
- W1130977540 title "Clinical utility of whole body scan in addition to cardiac FDG PET in the evaluation of active cardiac sarcoidosis" @default.
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