FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1131014054> ?p ?o ?g. }

• W1131014054 endingPage "81" @default.
• W1131014054 startingPage "76" @default.
• W1131014054 abstract "Absent in melanoma 2 (AIM2) is an intracellular pattern-recognition receptor, which is a member of the PYHIN protein family, consisting of a PYD domain and an IFN-inducible nuclear localization (HIN) domain. AIM2 is reported to oligomerize with adaptor protein ASC upon sensing bacterial and viral cytosolic DNA in order to form the AIM2 inflammasome, which activates caspase-1 leading to IL-1β secretion. Dysregulation of AIM2 inflammasome is supposed to result in autoinflammatory and autoimmune diseases. Thus, the development of new targeted drugs against AIM2 inflammasome would be important for the treatment of these diseases. However, since AIM2 inflammasome is an intracellular receptor, enforced internalization of both ligands and candidate molecules is necessary for the screening of AIM2-inflammasome-targeted molecules. We developed a reconstituted AIM2 inflammasome in a cell-free system with amplified luminescent proximity homogeneous assay (Alpha). Strong Alpha signal was detected upon incubation with poly-deoxyadenylic-deoxythymidylic acid, poly(dA:dT), whereas no Alpha signal was detected upon incubation with muramyl dipeptide, one of the NLR ligands of Nod2 ligand. The interaction between AIM2 and ASC was disrupted by an anti-human ASC monoclonal antibody, CRID3, a class of diarylsulfonylurea-containing compounds, and glycyrrhizin, a substance found in liquorice root. Thus, the reconstituted AIM2 inflammasome in a cell-free system is useful for screening AIM2-inflammasome-targeted therapeutic molecules." @default.
• W1131014054 created "2016-06-24" @default.
• W1131014054 creator A5005382110 @default.
• W1131014054 creator A5019414527 @default.
• W1131014054 creator A5019474102 @default.
• W1131014054 creator A5043103166 @default.
• W1131014054 creator A5051602851 @default.
• W1131014054 creator A5057574490 @default.
• W1131014054 creator A5061727322 @default.
• W1131014054 creator A5070326257 @default.
• W1131014054 creator A5074438688 @default.
• W1131014054 creator A5078618329 @default.
• W1131014054 creator A5081691633 @default.
• W1131014054 creator A5084390582 @default.
• W1131014054 date "2015-11-01" @default.
• W1131014054 modified "2023-10-17" @default.
• W1131014054 title "Reconstituted AIM2 inflammasome in cell-free system" @default.
• W1131014054 cites W118944295 @default.
• W1131014054 cites W169428739 @default.
• W1131014054 cites W1916083974 @default.
• W1131014054 cites W2015266107 @default.
• W1131014054 cites W2036007039 @default.
• W1131014054 cites W2037036600 @default.
• W1131014054 cites W2042288276 @default.
• W1131014054 cites W2042816890 @default.
• W1131014054 cites W2057871669 @default.
• W1131014054 cites W2064512362 @default.
• W1131014054 cites W2067603599 @default.
• W1131014054 cites W2072118838 @default.
• W1131014054 cites W2075583035 @default.
• W1131014054 cites W2083236593 @default.
• W1131014054 cites W2085006185 @default.
• W1131014054 cites W2098854209 @default.
• W1131014054 cites W2101118037 @default.
• W1131014054 cites W2111900042 @default.
• W1131014054 cites W2115617484 @default.
• W1131014054 cites W2118731963 @default.
• W1131014054 cites W2143244707 @default.
• W1131014054 cites W2156874253 @default.
• W1131014054 cites W2157305255 @default.
• W1131014054 cites W2158758822 @default.
• W1131014054 doi "https://doi.org/10.1016/j.jim.2015.08.004" @default.
• W1131014054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26259507" @default.
• W1131014054 hasPublicationYear "2015" @default.
• W1131014054 type Work @default.
• W1131014054 sameAs 1131014054 @default.
• W1131014054 citedByCount "7" @default.
• W1131014054 countsByYear W11310140542016 @default.
• W1131014054 countsByYear W11310140542017 @default.
• W1131014054 countsByYear W11310140542020 @default.
• W1131014054 countsByYear W11310140542021 @default.
• W1131014054 countsByYear W11310140542022 @default.
• W1131014054 crossrefType "journal-article" @default.
• W1131014054 hasAuthorship W1131014054A5005382110 @default.
• W1131014054 hasAuthorship W1131014054A5019414527 @default.
• W1131014054 hasAuthorship W1131014054A5019474102 @default.
• W1131014054 hasAuthorship W1131014054A5043103166 @default.
• W1131014054 hasAuthorship W1131014054A5051602851 @default.
• W1131014054 hasAuthorship W1131014054A5057574490 @default.
• W1131014054 hasAuthorship W1131014054A5061727322 @default.
• W1131014054 hasAuthorship W1131014054A5070326257 @default.
• W1131014054 hasAuthorship W1131014054A5074438688 @default.
• W1131014054 hasAuthorship W1131014054A5078618329 @default.
• W1131014054 hasAuthorship W1131014054A5081691633 @default.
• W1131014054 hasAuthorship W1131014054A5084390582 @default.
• W1131014054 hasConcept C136449434 @default.
• W1131014054 hasConcept C139964883 @default.
• W1131014054 hasConcept C153911025 @default.
• W1131014054 hasConcept C170493617 @default.
• W1131014054 hasConcept C183786373 @default.
• W1131014054 hasConcept C185592680 @default.
• W1131014054 hasConcept C187831198 @default.
• W1131014054 hasConcept C202751555 @default.
• W1131014054 hasConcept C2776444769 @default.
• W1131014054 hasConcept C2777209026 @default.
• W1131014054 hasConcept C55493867 @default.
• W1131014054 hasConcept C7573103 @default.
• W1131014054 hasConcept C86803240 @default.
• W1131014054 hasConcept C95444343 @default.
• W1131014054 hasConceptScore W1131014054C136449434 @default.
• W1131014054 hasConceptScore W1131014054C139964883 @default.
• W1131014054 hasConceptScore W1131014054C153911025 @default.
• W1131014054 hasConceptScore W1131014054C170493617 @default.
• W1131014054 hasConceptScore W1131014054C183786373 @default.
• W1131014054 hasConceptScore W1131014054C185592680 @default.
• W1131014054 hasConceptScore W1131014054C187831198 @default.
• W1131014054 hasConceptScore W1131014054C202751555 @default.
• W1131014054 hasConceptScore W1131014054C2776444769 @default.
• W1131014054 hasConceptScore W1131014054C2777209026 @default.
• W1131014054 hasConceptScore W1131014054C55493867 @default.
• W1131014054 hasConceptScore W1131014054C7573103 @default.
• W1131014054 hasConceptScore W1131014054C86803240 @default.
• W1131014054 hasConceptScore W1131014054C95444343 @default.
• W1131014054 hasLocation W11310140541 @default.
• W1131014054 hasLocation W11310140542 @default.
• W1131014054 hasOpenAccess W1131014054 @default.
• W1131014054 hasPrimaryLocation W11310140541 @default.
• W1131014054 hasRelatedWork W1131014054 @default.

• next