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- W11316274 abstract "A glycopeptide fraction (87% carbohydrate, 12.8% amino acids) with a potent, long lasting anorectic effect, in rats deprived of food for 96 hours, was separated from human serum. The endogenous substance, named satietin, was found to exert its anorectic effect in the rat after intracerebroventricular, intravenous, subcutaneous and oral administration. Satietin-activity was detected in the sera of different mammals (rat, guinea pig, rabbit, cat, dog, horse, cattle) and in a poultry (goose). In contrast to endogenous peptides with anorectic effect (like CCK and calcitonin) and to the drug-pair, amphetamine and fenfluramine, which represent the two main types of anti-obesity agents, satietin inhibited food intake without exerting any other central or peripheral effect. Considering the high satietin concentration in human serum and the unique selectivity and special features of its anorectic effect, the hypothesis was forwarded that satietin is the selective physiological stimulant of the serotonergic satiety system, and as such, it plays the role of a rate limiting satiety signal in the negative feed back of food intake." @default.
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- W11316274 date "1982-01-01" @default.
- W11316274 modified "2023-09-27" @default.
- W11316274 title "Anorectic Agents and Satietin, an Endogenous Inhibitor of Food Intake" @default.
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- W11316274 doi "https://doi.org/10.1016/b978-0-08-028021-9.50017-4" @default.
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