Matches in SemOpenAlex for { <https://semopenalex.org/work/W1132912678> ?p ?o ?g. }
- W1132912678 endingPage "232" @default.
- W1132912678 startingPage "221" @default.
- W1132912678 abstract "Abstract Over expression of 11β-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11β-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11β-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11β-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski’s rule and ADME prediction was implemented to find out the potent and selective 11 β-HSD 1 analog of corosolic acid without nephrotoxicity. Two compounds with NCBI compound identification number CID59752459 (Genins of Asiatic acid) and CID 119034 (Asiatic acid) were found to be selective for the 11β-HSD 1 enzyme without nephrotoxicity which comply with Lipinski’s rule and ADME parameter defined for human use. However, none of the hits inhibited 11β-HSD 2 at 100 μM indicating their selectivity against 11β-HSD 1." @default.
- W1132912678 created "2016-06-24" @default.
- W1132912678 creator A5026889066 @default.
- W1132912678 creator A5037629332 @default.
- W1132912678 creator A5040159716 @default.
- W1132912678 creator A5047579297 @default.
- W1132912678 creator A5064634732 @default.
- W1132912678 creator A5067234053 @default.
- W1132912678 creator A5071372385 @default.
- W1132912678 creator A5077006529 @default.
- W1132912678 creator A5087848582 @default.
- W1132912678 date "2018-02-01" @default.
- W1132912678 modified "2023-09-22" @default.
- W1132912678 title "In search of selective 11β-HSD type 1 inhibitors without nephrotoxicity: An approach to resolve the metabolic syndrome by virtual based screening" @default.
- W1132912678 cites W1536050246 @default.
- W1132912678 cites W1963987879 @default.
- W1132912678 cites W1972317154 @default.
- W1132912678 cites W1973562485 @default.
- W1132912678 cites W1974367155 @default.
- W1132912678 cites W1983597949 @default.
- W1132912678 cites W1988819811 @default.
- W1132912678 cites W2002955079 @default.
- W1132912678 cites W2009423060 @default.
- W1132912678 cites W2016125985 @default.
- W1132912678 cites W2024674972 @default.
- W1132912678 cites W2028212562 @default.
- W1132912678 cites W2033495141 @default.
- W1132912678 cites W2044468498 @default.
- W1132912678 cites W2046054946 @default.
- W1132912678 cites W2046355083 @default.
- W1132912678 cites W2056506557 @default.
- W1132912678 cites W2061962280 @default.
- W1132912678 cites W2073059190 @default.
- W1132912678 cites W2073745436 @default.
- W1132912678 cites W2078787576 @default.
- W1132912678 cites W2079329450 @default.
- W1132912678 cites W2082909564 @default.
- W1132912678 cites W2085553315 @default.
- W1132912678 cites W2087355987 @default.
- W1132912678 cites W2101439149 @default.
- W1132912678 cites W2101909530 @default.
- W1132912678 cites W2101935647 @default.
- W1132912678 cites W2117268230 @default.
- W1132912678 cites W2131882384 @default.
- W1132912678 cites W2135732933 @default.
- W1132912678 cites W2157970175 @default.
- W1132912678 cites W2951466690 @default.
- W1132912678 doi "https://doi.org/10.1016/j.arabjc.2015.08.003" @default.
- W1132912678 hasPublicationYear "2018" @default.
- W1132912678 type Work @default.
- W1132912678 sameAs 1132912678 @default.
- W1132912678 citedByCount "22" @default.
- W1132912678 countsByYear W11329126782016 @default.
- W1132912678 countsByYear W11329126782018 @default.
- W1132912678 countsByYear W11329126782019 @default.
- W1132912678 countsByYear W11329126782020 @default.
- W1132912678 countsByYear W11329126782021 @default.
- W1132912678 countsByYear W11329126782022 @default.
- W1132912678 countsByYear W11329126782023 @default.
- W1132912678 crossrefType "journal-article" @default.
- W1132912678 hasAuthorship W1132912678A5026889066 @default.
- W1132912678 hasAuthorship W1132912678A5037629332 @default.
- W1132912678 hasAuthorship W1132912678A5040159716 @default.
- W1132912678 hasAuthorship W1132912678A5047579297 @default.
- W1132912678 hasAuthorship W1132912678A5064634732 @default.
- W1132912678 hasAuthorship W1132912678A5067234053 @default.
- W1132912678 hasAuthorship W1132912678A5071372385 @default.
- W1132912678 hasAuthorship W1132912678A5077006529 @default.
- W1132912678 hasAuthorship W1132912678A5087848582 @default.
- W1132912678 hasBestOaLocation W11329126781 @default.
- W1132912678 hasConcept C103697762 @default.
- W1132912678 hasConcept C126189478 @default.
- W1132912678 hasConcept C126322002 @default.
- W1132912678 hasConcept C178790620 @default.
- W1132912678 hasConcept C185592680 @default.
- W1132912678 hasConcept C21951064 @default.
- W1132912678 hasConcept C2780578515 @default.
- W1132912678 hasConcept C29730261 @default.
- W1132912678 hasConcept C511355011 @default.
- W1132912678 hasConcept C55493867 @default.
- W1132912678 hasConcept C70721500 @default.
- W1132912678 hasConcept C71924100 @default.
- W1132912678 hasConcept C74187038 @default.
- W1132912678 hasConcept C86803240 @default.
- W1132912678 hasConcept C98274493 @default.
- W1132912678 hasConceptScore W1132912678C103697762 @default.
- W1132912678 hasConceptScore W1132912678C126189478 @default.
- W1132912678 hasConceptScore W1132912678C126322002 @default.
- W1132912678 hasConceptScore W1132912678C178790620 @default.
- W1132912678 hasConceptScore W1132912678C185592680 @default.
- W1132912678 hasConceptScore W1132912678C21951064 @default.
- W1132912678 hasConceptScore W1132912678C2780578515 @default.
- W1132912678 hasConceptScore W1132912678C29730261 @default.
- W1132912678 hasConceptScore W1132912678C511355011 @default.
- W1132912678 hasConceptScore W1132912678C55493867 @default.
- W1132912678 hasConceptScore W1132912678C70721500 @default.
- W1132912678 hasConceptScore W1132912678C71924100 @default.
- W1132912678 hasConceptScore W1132912678C74187038 @default.