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- W1133139007 abstract "Publisher Summary This chapter describes the characteristics of antibodies, which are crucial for blocking the biological activity of neuropeptides, and on the basis of the mechanism of action explains apparent contradictory results. The results presented clearly demonstrate that the binding capacity of an antibody is not a relevant predictor of its biological activity. What counts in passive immunization studies is whether the antibody concentration present in the compartment involved in signal transfer is sufficiently high to bind a significant proportion of the peptide within the signaling time. Thus, based on present knowledge, passive immunization is likely to interfere with (neuro) hormonal and slow nonsynaptic forms of transmission, whereas interference with fast forms of neurotransmission is unlikely. The large number of studies in which biological effects have been recorded after intracerebral administration of antibodies to neuropeptides, thus suggest that nonsynaptic forms of peptidergic signal transfer represent a major type of communication of peptidergic neurons in the mammalian brain." @default.
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- W1133139007 date "1992-01-01" @default.
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- W1133139007 title "Chapter 19 Antibodies to neuropeptides as alternatives for peptide receptor antagonists in studies on the physiological actions of neuropeptides" @default.
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- W1133139007 doi "https://doi.org/10.1016/s0079-6123(08)61178-4" @default.
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