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- W1133199696 abstract "Dietary phytochemicals and prescription drugs are xenobiotics tohuman cells and are substrates of the same enzymes and transporters dedicatedto biotransformation, detoxification and elimination. The interactions betweenphytochemicals and phase I and II biotransformation enzymes, as well as theirsystems of regulation, can often explain their known anticarcinogenic orantioxidant actions. However, for the same reason the contemporaneous intakeof phytochemicals and drugs may result in the alteration of drug biodispositionand efficacy. In the present chapter the principal routes of biotransformation aredescribed, as well as the mechanisms underlying their concerted regulation, andthe biotransformation of the most significant phytochemicals is reported.Examples of phytochemicals/drugs interaction are illustrated and the importanceof this issue for phytochemical supplementation is pointed out." @default.
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- W1133199696 date "2010-01-01" @default.
- W1133199696 modified "2023-09-23" @default.
- W1133199696 title "Dietary phytochemicals and drugs: potential consequences of a common metabolism." @default.
- W1133199696 hasPublicationYear "2010" @default.
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