FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1133356780> ?p ?o ?g. }

• W1133356780 endingPage "354" @default.
• W1133356780 startingPage "334" @default.
• W1133356780 abstract "This chapter reviews the methodology by which an asymmetric substrate can be conceptually modified to produce structurally diverse symmetric and pseudosymmetric inhibitors of the C2-symmetric enzyme HIV protease. The exact placement of the C2-axis and the choice of terminus of the substrate to be duplicated determine the position of key functionality of the resulting symmetric core unit and can be a major determinant in the binding constant of the resulting inhibitor. The chapter describes the relative importance of the interactions of various functionality in symmetric core units with the HIV protease active site should provide guidance for the design of novel, symmetric inhibitors. Judicious applications of the above principles to asymmetric inhibitors should provide new generations of symmetry-based inhibitor structures. Through random screening and de novo design, other C2-symmetric or pseudosymmetric inhibitors of HIV protease that do not resemble substrate structure are likely to be discovered. The design of cyclic inhibitor XLII legitimates the synergistic role that computer modeling and medicinal chemistry will play in the future of drug design in this important area." @default.
• W1133356780 created "2016-06-24" @default.
• W1133356780 creator A5018188145 @default.
• W1133356780 date "1994-01-01" @default.
• W1133356780 modified "2023-10-14" @default.
• W1133356780 title "[18] Design of symmetry-based, peptidomimetic inhibitors of human immunodeficiency virus protease" @default.
• W1133356780 cites W1966952510 @default.
• W1133356780 cites W1977016185 @default.
• W1133356780 cites W1977672660 @default.
• W1133356780 cites W1983066351 @default.
• W1133356780 cites W1987688509 @default.
• W1133356780 cites W2002360200 @default.
• W1133356780 cites W2012108232 @default.
• W1133356780 cites W2041299378 @default.
• W1133356780 cites W2053718280 @default.
• W1133356780 cites W2058898122 @default.
• W1133356780 cites W2064223671 @default.
• W1133356780 cites W2065134897 @default.
• W1133356780 cites W2069366448 @default.
• W1133356780 cites W2070753408 @default.
• W1133356780 cites W2071265228 @default.
• W1133356780 cites W2101988854 @default.
• W1133356780 cites W2155894418 @default.
• W1133356780 cites W2157809663 @default.
• W1133356780 cites W2951545754 @default.
• W1133356780 cites W4252671483 @default.
• W1133356780 doi "https://doi.org/10.1016/0076-6879(94)41072-0" @default.
• W1133356780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7854187" @default.
• W1133356780 hasPublicationYear "1994" @default.
• W1133356780 type Work @default.
• W1133356780 sameAs 1133356780 @default.
• W1133356780 citedByCount "38" @default.
• W1133356780 countsByYear W11333567802012 @default.
• W1133356780 countsByYear W11333567802013 @default.
• W1133356780 countsByYear W11333567802015 @default.
• W1133356780 countsByYear W11333567802019 @default.
• W1133356780 countsByYear W11333567802022 @default.
• W1133356780 crossrefType "book-chapter" @default.
• W1133356780 hasAuthorship W1133356780A5018188145 @default.
• W1133356780 hasConcept C124790011 @default.
• W1133356780 hasConcept C142462285 @default.
• W1133356780 hasConcept C159047783 @default.
• W1133356780 hasConcept C181199279 @default.
• W1133356780 hasConcept C185592680 @default.
• W1133356780 hasConcept C18903297 @default.
• W1133356780 hasConcept C21951064 @default.
• W1133356780 hasConcept C2524010 @default.
• W1133356780 hasConcept C2776714187 @default.
• W1133356780 hasConcept C2777289219 @default.
• W1133356780 hasConcept C2777583353 @default.
• W1133356780 hasConcept C2779281246 @default.
• W1133356780 hasConcept C2779886137 @default.
• W1133356780 hasConcept C2781143361 @default.
• W1133356780 hasConcept C2993143319 @default.
• W1133356780 hasConcept C3013748606 @default.
• W1133356780 hasConcept C33923547 @default.
• W1133356780 hasConcept C41183919 @default.
• W1133356780 hasConcept C55493867 @default.
• W1133356780 hasConcept C71240020 @default.
• W1133356780 hasConcept C86803240 @default.
• W1133356780 hasConceptScore W1133356780C124790011 @default.
• W1133356780 hasConceptScore W1133356780C142462285 @default.
• W1133356780 hasConceptScore W1133356780C159047783 @default.
• W1133356780 hasConceptScore W1133356780C181199279 @default.
• W1133356780 hasConceptScore W1133356780C185592680 @default.
• W1133356780 hasConceptScore W1133356780C18903297 @default.
• W1133356780 hasConceptScore W1133356780C21951064 @default.
• W1133356780 hasConceptScore W1133356780C2524010 @default.
• W1133356780 hasConceptScore W1133356780C2776714187 @default.
• W1133356780 hasConceptScore W1133356780C2777289219 @default.
• W1133356780 hasConceptScore W1133356780C2777583353 @default.
• W1133356780 hasConceptScore W1133356780C2779281246 @default.
• W1133356780 hasConceptScore W1133356780C2779886137 @default.
• W1133356780 hasConceptScore W1133356780C2781143361 @default.
• W1133356780 hasConceptScore W1133356780C2993143319 @default.
• W1133356780 hasConceptScore W1133356780C3013748606 @default.
• W1133356780 hasConceptScore W1133356780C33923547 @default.
• W1133356780 hasConceptScore W1133356780C41183919 @default.
• W1133356780 hasConceptScore W1133356780C55493867 @default.
• W1133356780 hasConceptScore W1133356780C71240020 @default.
• W1133356780 hasConceptScore W1133356780C86803240 @default.
• W1133356780 hasLocation W11333567801 @default.
• W1133356780 hasLocation W11333567802 @default.
• W1133356780 hasOpenAccess W1133356780 @default.
• W1133356780 hasPrimaryLocation W11333567801 @default.
• W1133356780 hasRelatedWork W193287362 @default.
• W1133356780 hasRelatedWork W1978507884 @default.
• W1133356780 hasRelatedWork W1991243909 @default.
• W1133356780 hasRelatedWork W2013520316 @default.
• W1133356780 hasRelatedWork W2014958964 @default.
• W1133356780 hasRelatedWork W2042479326 @default.
• W1133356780 hasRelatedWork W2092115647 @default.
• W1133356780 hasRelatedWork W2106076589 @default.
• W1133356780 hasRelatedWork W2506150632 @default.
• W1133356780 hasRelatedWork W3161520842 @default.
• W1133356780 isParatext "false" @default.
• W1133356780 isRetracted "false" @default.
• W1133356780 magId "1133356780" @default.

• next