Matches in SemOpenAlex for { <https://semopenalex.org/work/W1133825458> ?p ?o ?g. }
- W1133825458 endingPage "172" @default.
- W1133825458 startingPage "147" @default.
- W1133825458 abstract "This chapter focuses on regulation of the gap junction protein connexin43 (cx43) and its functional correlate in gap junctional coupling by brain region heterogeneity and by growth hormone (GH) and insulin-like growth factor I (IGF-I). In astroglial cells, cx43 is the dominant connexin making up gap junctions. It is noted that GH and IGF-I have been shown to affect levels of neurotransmitters in the brain, myelination, and cognition. As glial cells express receptors for GH and IGF-I it is hypothesized that these hormones could affect astrocytic gap junctions and cx43. The effects of bovine GH (bGH) and recombinant human IGF-I (rhlGF-l) on cx43 expression and gap junctional coupling (GJC) are studied in vivo and in vitro. The astroglial cells secreted Insulin-like growth factor binding proteins (IGBFPs) in vitro and a high abundance of these are associated with a low response to rhlGF-I The results indicate that the effect of GH on cx43 expression in vivo may be mediated locally by IGF-I and interactions with insulin-like growth factor binding protein." @default.
- W1133825458 created "2016-06-24" @default.
- W1133825458 creator A5019548859 @default.
- W1133825458 date "2006-01-01" @default.
- W1133825458 modified "2023-09-27" @default.
- W1133825458 title "Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junctions" @default.
- W1133825458 cites W1509216925 @default.
- W1133825458 cites W1517261517 @default.
- W1133825458 cites W1588052927 @default.
- W1133825458 cites W1590558744 @default.
- W1133825458 cites W1600549717 @default.
- W1133825458 cites W1629086159 @default.
- W1133825458 cites W1642980781 @default.
- W1133825458 cites W1654040390 @default.
- W1133825458 cites W168276155 @default.
- W1133825458 cites W176731367 @default.
- W1133825458 cites W1903272649 @default.
- W1133825458 cites W1904228445 @default.
- W1133825458 cites W1914852136 @default.
- W1133825458 cites W1925508137 @default.
- W1133825458 cites W1940105614 @default.
- W1133825458 cites W1944094967 @default.
- W1133825458 cites W1959780907 @default.
- W1133825458 cites W1963622071 @default.
- W1133825458 cites W1964122573 @default.
- W1133825458 cites W1964405560 @default.
- W1133825458 cites W1965972342 @default.
- W1133825458 cites W1966864860 @default.
- W1133825458 cites W1967383091 @default.
- W1133825458 cites W1969501028 @default.
- W1133825458 cites W1970549117 @default.
- W1133825458 cites W1972304812 @default.
- W1133825458 cites W1973706438 @default.
- W1133825458 cites W1973839541 @default.
- W1133825458 cites W1974501699 @default.
- W1133825458 cites W1975581419 @default.
- W1133825458 cites W1976136395 @default.
- W1133825458 cites W1979227386 @default.
- W1133825458 cites W1979827495 @default.
- W1133825458 cites W1980034899 @default.
- W1133825458 cites W1980504779 @default.
- W1133825458 cites W1980900081 @default.
- W1133825458 cites W1982659377 @default.
- W1133825458 cites W1984200333 @default.
- W1133825458 cites W1984830318 @default.
- W1133825458 cites W1987080089 @default.
- W1133825458 cites W1987301484 @default.
- W1133825458 cites W1987391644 @default.
- W1133825458 cites W1987508789 @default.
- W1133825458 cites W1987924658 @default.
- W1133825458 cites W1989602097 @default.
- W1133825458 cites W1989677035 @default.
- W1133825458 cites W1990331706 @default.
- W1133825458 cites W1990341941 @default.
- W1133825458 cites W1991022719 @default.
- W1133825458 cites W1991853914 @default.
- W1133825458 cites W1992269944 @default.
- W1133825458 cites W1993755617 @default.
- W1133825458 cites W1993873975 @default.
- W1133825458 cites W1994516289 @default.
- W1133825458 cites W1995361556 @default.
- W1133825458 cites W1995728225 @default.
- W1133825458 cites W1995748663 @default.
- W1133825458 cites W1997899631 @default.
- W1133825458 cites W1998282583 @default.
- W1133825458 cites W1998794365 @default.
- W1133825458 cites W1998906848 @default.
- W1133825458 cites W2003688881 @default.
- W1133825458 cites W2003738680 @default.
- W1133825458 cites W2006471079 @default.
- W1133825458 cites W2008033907 @default.
- W1133825458 cites W2008319863 @default.
- W1133825458 cites W2008418293 @default.
- W1133825458 cites W2008831180 @default.
- W1133825458 cites W2010856791 @default.
- W1133825458 cites W2012654459 @default.
- W1133825458 cites W2013007296 @default.
- W1133825458 cites W2014418366 @default.
- W1133825458 cites W2015173171 @default.
- W1133825458 cites W2015908426 @default.
- W1133825458 cites W2016337945 @default.
- W1133825458 cites W2018316528 @default.
- W1133825458 cites W2018668449 @default.
- W1133825458 cites W2019988911 @default.
- W1133825458 cites W2020005796 @default.
- W1133825458 cites W2020336800 @default.
- W1133825458 cites W2020492419 @default.
- W1133825458 cites W2020715437 @default.
- W1133825458 cites W2021800931 @default.
- W1133825458 cites W2022263881 @default.
- W1133825458 cites W2022541264 @default.
- W1133825458 cites W2022602979 @default.
- W1133825458 cites W2022992417 @default.
- W1133825458 cites W2024310292 @default.
- W1133825458 cites W2024537012 @default.
- W1133825458 cites W2026491913 @default.
- W1133825458 cites W2027164878 @default.
- W1133825458 cites W2027260046 @default.