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- W113397269 abstract "The Na+/K+ pump of animal cells extrudes 3 Na+ from the cell interior and takes up 2 K+ per ATP molecule hydrolysed. Thereby the transport generates the pump current Ip which is an outward current under physiological conditions. The chemical and electrical work, which can be performed by the pump, depends on the free energy of the pump’s ATP hydrolysis (ΔGATP). If intracellular Na+ and external Cs+ are pumped the following equation should hold: $$ Delta textup{G}_{textup{ATP}}=textup{F x} left ( textup{E}_{textup{rev}}-3textup{E}_{textup{Na}}+textup{2 E}_{textup{Cs}} right)left ( textup{eqn}.1 right ) $$. F is the Faraday constant; ENa and ECs stand for the Na+ and Cs+ equilibrium potential, respectively. Thus at fixed Na+ and Cs+ gradients across the cell membrane Erev, the membrane potential where Ip changes its sign, is expected to vary with ΔGATP. To test this expectation we have carried out experiments on isolated, cultured cardiac cells. Some results of these experiments are described below." @default.
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- W113397269 date "1994-01-01" @default.
- W113397269 modified "2023-09-25" @default.
- W113397269 title "Reversal potential of Na+ pump current in cardioballs at various ΔG of ATP hydrolysis" @default.
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- W113397269 doi "https://doi.org/10.1007/978-3-642-72511-1_93" @default.
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